AB15102 | Anti-Mint-1 Antibody

AB15102
100 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB15102
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Mint-1 Antibody
      References
      Product Information
      FormatSerum
      PresentationLiquid
      Applications
      ApplicationDetect Mint-1 using this Anti-Mint-1 Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:5,000-1:10,000 using ECL (5 min exposure)
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from rat.
      HostRabbit
      SpecificityMint-1. By Western blot the antibody recognizes a band at ~130 kDa in rat brain lysate.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
      Gene Symbol
      • APBA1
      • D9S411E
      • X11
      • X11A
      • X11ALPHA
      • MINT1
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q02410 # Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta- amyloid precursor protein (APP) and hence formation of beta-APP.
      SIZE: 837 amino acids; 92865 Da
      SUBUNIT: Part of a multimeric complex containing Munc18-1 and syntaxin-1. Also part of the brain-specific heterotrimeric complex LIN-10/X11-alpha, LIN-2/CASK, and LIN7. Binds to the cytoplasmic domain of amyloid protein (APP).
      TISSUE SPECIFICITY: Brain and spinal cord.
      DOMAIN: SwissProt: Q02410 Composed of an N-terminal domain that binds Munc18-1 and LIN-2/CASK, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the beta-amyloid precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.
      SIMILARITY: Contains 2 PDZ (DHR) domains. & Contains 1 PID domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-MINT-1 -2765902 2765902
      RABBIT ANTI-MINT-1 -2818210 2818210

      References

      Reference overviewApplicationPub Med ID
      TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.
      Alpern, D; Langer, D; Ballester, B; Le Gras, S; Romier, C; Mengus, G; Davidson, I
      eLife  3  e03613  2014

      Show Abstract
      Immunofluorescence25209997 25209997

      Data Sheet

      Title
      Mint1 - Data Sheet