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MAB362 Anti-MAP1 Antibody, clone HM-1

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MAB362
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICC, IHCMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB362
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MAP1 Antibody, clone HM-1
      Alternate Names
      • Microtubule-Associated Protein
      References
      Product Information
      FormatAscites
      PresentationAscites fluid. Liquid containing 15mM sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect MAP1 using this Anti-MAP1 Antibody, clone HM-1 validated for use in WB, IC, IH.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunoblotting at 1:500 using fresh rat brain extract or enriched microtubule protein preparation.

      Immunocytochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRat brain microtubule-associated protein.
      CloneHM-1
      HostMouse
      SpecificityReacts specifically with MAP1 (also known as MAP 1a) on immunoblots of whole brain homogenate proteins. Shows selective staining of neurons and stronger staining of axons and dendrites in immunohistochemistry staining of brain tissue. Stains both the cell bodies and dendritic trees. No cross-reactivity observed to other MAPs or tubulin.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development.
      Gene Symbol
      • MAP1A
      • FLJ77111
      • MTAP1A
      • MAP1L
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P78559 # Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements.
      SIZE: 2805 amino acids; 306482 Da
      SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with guanylate kinase- like domain of DLG1, DLG2 and DLG4 (By similarity).
      TISSUE SPECIFICITY: Brain.
      DOMAIN: SwissProt: P78559 The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
      PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. & LC2 is generated from MAP1A by proteolytic processing.
      SIMILARITY: Belongs to the MAP1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

      During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For antibodies with volumes of 200 μL or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container's cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-MAP1 Antibody, clone HM-1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-MAP1 Antibody, clone HM-1 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-MAP1 MONOCLONAL ANTIBODY - 2383945 2383945
      MOUSE ANTI-MAP1 MONOCLONAL ANTIBODY - 2410980 2410980
      MOUSE ANTI-MAP1 MONOCLONAL ANTIBODY - 2435032 2435032
      MOUSE ANTI-MAP1 - 3385696 3385696
      MOUSE ANTI-MAP1 - 3587162 3587162
      MOUSE ANTI-MAP1 -2801983 2801983
      MOUSE ANTI-MAP1 -2805173 2805173
      MOUSE ANTI-MAP1 -2831792 2831792
      MOUSE ANTI-MAP1 MONOCLONAL ANTIBODY 2900236
      MOUSE ANTI-MAP1 MONOCLONAL ANTIBODY 2885362

      References

      Reference overviewPub Med ID
      Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons.
      Zhang, L; Gavin, T; DeCaprio, AP; LoPachin, RM
      Toxicological sciences : an official journal of the Society of Toxicology  117  180-9  2010

      Show Abstract
      20554699 20554699
      Heterogeneous distribution of axonal cytoskeleton proteins in the human optic nerve.
      Chandrakumar Balaratnasingam, William H Morgan, Victoria Johnstone, Stephen J Cringle, Dao-Yi Yu
      Investigative ophthalmology visual science  50  2824-38  2009

      Show Abstract
      19168905 19168905
      The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain.
      R M Douglas, J C K Lai, S Bian, L Cummins, E Moczydlowski, G G Haddad
      Neuroscience  139  1249-61  2006

      Show Abstract
      16567053 16567053
      Differences in the cellular distributions of two microtubule-associated proteins, MAP1 and MAP2, in rat brain.
      Huber, G and Matus, A
      J. Neurosci., 4: 151-60 (1984)  1984

      Show Abstract
      6198491 6198491

      Data Sheet

      Title
      MOUSE ANTI-MAP1