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AB2988 Anti-LYVE1 Antibody

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AB2988
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB2988
      Replaces07-538
      DescriptionAnti-LYVE1 Antibody
      Alternate Names
      • Cell surface retention sequence-binding protein 1
      • Extracellular link domain-containing protein 1
      • Hyaluronic acid receptor
      • cell surface retention sequence binding protein-1
      • extracellular link domain containing 1
      • extracellular link domain-containing 1
      • lymphatic vessel endothelial hyaluronan receptor 1
      Background InformationLYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 may function in lymphatic hyaluronan transport. Additionally, LYVE1 has a role in tumor metastasis.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Ovarian cancer tissue
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LYVE1 Antibody is an antibody against LYVE1 for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesNot recommended to work in western blot using mouse liver lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to mouse LYVE1.
      EpitopeUnknown
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes LYVE1.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Species Reactivity NoteDemonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. Rat (90% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.
      Gene Symbol
      • LYVE1
      • CRSBP-1
      • CRSBP1
      • HARl
      • LYVE-1
      • XLKD1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

      SUBUNIT STRUCTURE: Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Note: Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.

      PTM: O-glycosylated By similarity.

      SEQUENCE SIMILARITIES: Contains 1 Link domain.
      Molecular Weight~ 40 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in ovarian cancer tissue.

      Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected LYVE1 in ovarian cancer tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-LYVE1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-LYVE1 Antibody Certificates of Analysis

      TitleLot Number
      Anti-Lyve-1 - 2370192 2370192
      Anti-Lyve-1 - 2450203 2450203
      Anti-Lyve-1 - 1940540 1940540
      Anti-Lyve-1 - 1979949 1979949
      Anti-Lyve-1 - 2022065 2022065
      Anti-Lyve-1 - 2061568 2061568
      Anti-Lyve-1 - 2196195 2196195
      Anti-Lyve-1 - 2280492 2280492
      Anti-Lyve-1 - 3321124 3321124
      Anti-Lyve-1 - 3698148 3698148

      References

      Reference overviewApplicationPub Med ID
      A novel role for ezrin in breast cancer angio/lymphangiogenesis.
      Ghaffari, A; Hoskin, V; Szeto, A; Hum, M; Liaghati, N; Nakatsu, K; LeBrun, D; Madarnas, Y; Sengupta, S; Elliott, BE
      Breast cancer research : BCR  16  438  2014

      Show Abstract
      Immunohistochemistry25231728 25231728