ABS600 Anti-LNPEP Antibody

ABS600
150 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberABS600
      DescriptionAnti-LNPEP Antibody
      Alternate Names
      • Leucyl-cystinyl aminopeptidase
      • Cystinyl aminopeptidase
      • Insulin-regulated membrane aminopeptidase
      • Insulin-responsive aminopeptidase
      • IRAP
      • Oxytocinase
      • Otase
      • Placental leucine aminopeptidase
      • P-LAP
      • LNPEP
      Background InformationThe protein named Leucyl-cystinyl aminopeptidase, or alternatively Cystinyl aminopeptidase, or Insulin-regulated membrane aminopeptidase, Insulin-responsive aminopeptidase (IRAP), Oxytocinase (OTase), or Placental leucine aminopeptidase (P-LAP) and encoded by the human gene named LNPEP/OTASE is an important aminopeptidase that plays an important role in maintaining homeostasis during pregnancy. LNPEP degrades peptide hormones including oxytocin, vasopressin, and angiotensin III; it also appears to play a role in degrading neuronal peptides in the brain such as Met-enkephalin and dynorphin. LNPEP also binds angiotensin IV and appears to be the receptor for angiotensin IV in the brain. LNPEP is a membrane bound aminopeptidase and is often found within membrane vesicles that together with other proteins like GLUT4 translocates to the plasma membrane in response to insulin or oxytocin. A cleaved fragment of LNPEP, the Leucyl-cystinyl aminopeptidase, is found in the blood during pregnancy, low in the first trimester but rising rapidly until birth, whereby it decreases rapidly, thus the secreted form is often used as a pregnancy marker.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.
      Applications
      ApplicationAnti-LNPEP antibody detects level of LNPEP & has been published & validated for use in LNPEP.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected LNPEP in human heart tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human LNPEP.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • LNPEP
      • OTASE
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~120 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: A 1:800 dilution of this antibody detected LNPEP in human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size150 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies