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MAB1617 Anti-Kinesin Antibody, light chain, clone L2

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MAB1617
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MaELISA, IP, RIA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1617
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Kinesin Antibody, light chain, clone L2
      References
      Product Information
      FormatPurified
      PresentationLiquid in 0.02 M Phosphate buffer, 0.25 M NaCl with 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Kinesin Antibody, light chain, clone L2 is an antibody against Kinesin for use in ELISA, IP, RIA & WB.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Radioimmunoassay
      • Western Blotting
      Application NotesImmunoblotting

      Immunoprecipitation

      EIA/RIA

      Optimal working dilutions must be determined by the end user.

      Note: Does not work for immunohistochemistry and works only marginally for immunocytochemistry.
      Biological Information
      ImmunogenBovine brain kinesin.
      Epitopelight chain
      CloneL2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with the light chain of kinesin near the C-terminal.
      IsotypeIgG2a
      Species Reactivity
      • Mammals
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryConventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.
      Gene Symbol
      • KLC1
      • hKLC1R
      • KNS2
      • KLC
      • KNS2A
      • hKLC1S
      • hKLC1P
      • hKLC1N
      • MGC15245
      • hKLC1J
      • hKLC1G
      • hKLC1B
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q07866 # Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
      SIZE: 569 amino acids; 64786 Da
      SUBUNIT: Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9 (By similarity).
      TISSUE SPECIFICITY: Found in a variety of tissues. Mostly abundant in brain and spine.
      PTM: Isoform I is phosphorylated on Ser-596.
      SIMILARITY: SwissProt: Q07866 ## Belongs to the kinesin light chain family. & Contains 6 TPR repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Kinesin Antibody, light chain, clone L2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Kinesin Antibody, light chain, clone L2 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-KINESIN, LIGHT CHAIN 2482726
      MOUSE ANTI-KINESIN, LIGHT CHAIN MONOCLONAL ANTIBODY - 2411813 2411813
      MOUSE ANTI-KINESIN, LIGHT CHAIN MONOCLONAL ANTIBODY - 2159630 2159630
      MOUSE ANTI-KINESIN, LIGHT CHAIN - 3757091 3757091
      MOUSE ANTI-KINESIN, LIGHT CHAIN -2575154 2575154
      MOUSE ANTI-KINESIN, LIGHT CHAIN MONOCLONAL ANTIBODY 2874463

      References

      Reference overviewApplicationPub Med ID
      Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome.
      Johnson, C; Tinti, M; Wood, NT; Campbell, DG; Toth, R; Dubois, F; Geraghty, KM; Wong, BH; Brown, LJ; Tyler, J; Gernez, A; Chen, S; Synowsky, S; MacKintosh, C
      Molecular & cellular proteomics : MCP  10  M110.005751  2011

      Show Abstract
      21725060 21725060
      Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3.
      Tateno, M; Kato, S; Sakurai, T; Nukina, N; Takahashi, R; Araki, T
      Human molecular genetics  18  942-55  2009

      Show Abstract
      Western Blotting19088126 19088126
      Fast axonal transport of kinesin in the rat visual system: functionality of kinesin heavy chain isoforms.
      Elluru, R G, et al.
      Mol. Biol. Cell, 6: 21-40 (1995)  1995

      Show Abstract
      7538359 7538359
      Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration.
      Hirokawa, N, et al.
      Cell, 56: 867-78 (1989)  1989

      Show Abstract
      2522351 2522351
      Monoclonal antibodies to kinesin heavy and light chains stain vesicle-like structures, but not microtubules, in cultured cells.
      Pfister, K K, et al.
      J. Cell Biol., 108: 1453-63 (1989)  1989

      Show Abstract
      2522455 2522455

      Data Sheet

      Title
      MOUSE ANTI-KINESIN, LIGHT CHAIN MONOCLONAL ANTIBODY