MABT86 Anti-Keratocan Antibody, clone KER-1

100 µg  
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      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R, B WB, IHC M Purified Monoclonal Antibody
      Catalogue NumberMABT86
      DescriptionAnti-Keratocan Antibody, clone KER-1
      Alternate Names
      • KTN
      • Corneal keratan sulfate proteoglycan 37A core protein
      • Keratan sulfate proteoglycan keratocan
      • KSPG keratocan
      Background InformationKeratocan is an extracellular matrix protein that belongs to the small leucine-rich proteoglycan (SLRP) family that also includes lumican, biglycan, decorin, mimecan, and fibromodulin. Members of this family are known to regulate cellular processes, such as proliferation and modulation of osteoprogenitor lineage differentiation. Keratocan is differentially expressed by osteoblasts and shows little or no expression in osteocytes. Lumican and Keratocan are the major keratan sulfate (KS) proteoglycans in corneal stroma. Both proteins are critical for normal cornea morphogenesis during embryonic development and maintenance of corneal topography in adults. It is shown that homozygous Keratocan knockout mice display abnormal corneas, significantly decreased rates of bone formation and mineral apposition, larger fibril diameters, and disorganized fibril spacing. Keratocan mutation leads to cornea plana in humans, which is often associated with glaucoma. Experimental evidence indicates that lumican may have additional biological functions, such as modulation of cell migration and epithelium-mesenchyme transition in wound healing and tumorgenesis, aside from regulating collagen fibrillogenesis.
      Product Information
      • Rat eye tissue lysate.
      PresentationPurified mouse monocolonal IgMk in buffer containing PBS with 0.05% sodium azide.
      ApplicationAnti-Keratocan Antibody, clone KER-1 detects level of Keratocan & has been published & validated for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A previous lot from an independent laboratory detected Keratocan in the anterior stroma of developing chick corneas. (Gealy, E.C., et al. (2007). Histochem Cell Biol. 128(6):551-555.)
      Biological Information
      ImmunogenKeratocan from partially purified keritinase II-treated bovine corneal extract.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      Species Reactivity
      • Rat
      • Bovine
      Species Reactivity NoteDemonstrated to react with Rat. Predicted to react with Bovine based on immunogen design.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KERA
      Purification MethodPurified by Ion-Exchange Chromatography
      UniProt Number
      UniProt SummaryFUNCTION: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix (By similarity).

      SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.

      TISSUE SPECIFICITY: Abundant in cornea and sclera but also found in other tissues.
      Molecular Weight~40 kDa observed
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in rat eye tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Keratocan in 10 µg of rat eye tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information