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MABE315 Anti-JMJD2C Antibody, clone 6A3.1

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MABE315
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE315
      DescriptionAnti-JMJD2C Antibody, clone 6A3.1
      Alternate Names
      • Lysine-specific demethylase 4C
      • Gene amplified in squamous cell carcinoma 1 protein
      • GASC-1 protein
      • JmjC domain-containing histone demethylation protein 3C
      • Jumonji domain-containing protein 2C
      Background InformationJMJD2C, also known as Lysine-specific demethylase 4C, and encoded by the gene KDM4C/ GASC1/ JHDM3C/ JMJD2C/ KIAA0780, is a histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. JMJD2C does not demethylate histone H3 'Lys-4', H3 'Lys-27', nor H4 'Lys-20'. JMJD2C can also demethylate trimethylated H3 'Lys-9' and H3 'Lys-36' residues, but JMJD2C has no activity on mono- and dimethylated residues. JMJD2C is overexpressed in several esophageal squamouse cancer cells and serves as a cancer marker for such cancers. This gene is also amplified in squamous cell carcinoma 1 protein (GASC-1). By demethylating H3K9me, JMJD2C/KDM4C acts as a transcription promoter on many target genes including genes the affect cell growth in normal or cancer cells. JMJD2C also regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells and thus is a target for anti-cancer therapy for this disease.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-JMJD2C Antibody, clone 6A3.1 is an antibody against JMJD2C for use in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:250 dilution from a representative lot detected JMJD2C in HeLa cells.

      Alexa Fluor® is a registered trademark of Life Technologies®.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human JMJD2C.
      Clone6A3.1
      Concentration0.5 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KDM4C
      • GASC1
      • JHDM3C
      • JMJD2C
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~120 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa nuclear extract.

      Western Blotting Analysis: 1 µg/mL of this antibody detected JMJD2C in 10 µg of HeLa neclear extract.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications