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AB5354 Anti-Internexin α Antibody

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AB5354
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MaELISA, WB, ICC, IHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB5354
      Replaces04-1032
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Internexin α Antibody
      References
      Product Information
      FormatSerum
      Control
      • POSITIVE CONTROL CELLS: PC12, Ntera2.
      PresentationSerum liquid, containing no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Internexin Antibody, α is an antibody against Internexin for use in ELISA, WB, IC, IH.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry
      Application NotesImmunohistochemistry on formalin or paraformaldehyde fixed tissues.

      Immunocytochemistry.

      Western blot: using human or rat brain homogenates.

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenFull length recombinant rat alpha-internexin fused to E. coli Trp E.
      HostRabbit
      Specificityalpha-internexin, C-terminal globular "tail" region. By western blot, AB5354 detects a major band at 66 kDa and a minor band at approximately 150 kDa corresponding to alpha internexin monomer and dimer, respectively. A minor band at approximately 50 kDa is occasionally detected and is believed to be a degradation product of alpha internexin. This antibody has been referred to in the literature as the R36 antibody (Evans, 2002).
      Species Reactivity
      • Mammals
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • INA
      • NF-66
      • NEF5
      • MGC12702
      • Alpha-Inx
      • TXBP-1
      • Neurofilament-66
      • Alpha-internexin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q16352 # Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges.
      SIZE: 499 amino acids; 55391 Da
      TISSUE SPECIFICITY: Found predominantly in adult CNS.
      DEVELOPMENTAL STAGE: Expressed in brain as early as the 16th week of gestation, and increased rapidly and reached a steady state level by the 18th week of gestation.
      PTM: O-glycosylated (By similarity). & Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: Q16352 ## Belongs to the intermediate filament family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Internexin α Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Internexin α Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-#945;-INTERNEXIN POLYCLONAL ANTIBODY - 2123633 2123633
      RABBIT ANTI-a-INTERNEXIN POLYCLONAL ANTIBODY 2914983
      RABBIT ANTI-a-INTERNEXIN POLYCLONAL ANTIBODY - 2111375 2111375
      RABBIT ANTI-a-INTERNEXIN POLYCLONAL ANTIBODY - 2197125 2197125
      RABBIT ANTI-a-INTERNEXIN POLYCLONAL ANTIBODY - 2208747 2208747
      RABBIT ANTI-α-INTERNEXIN - 3385692 3385692
      RABBIT ANTI-α-INTERNEXIN - 3697977 3697977
      RABBIT ANTI-α-INTERNEXIN POLYCLONAL ANTIBODY 3005362
      RABBIT ANTI-α-INTERNEXIN POLYCLONAL ANTIBODY - 2462714 2462714
      RABBIT ANTI-α-INTERNEXIN POLYCLONAL ANTIBODY - 3543883 3543883

      References

      Reference overviewApplicationPub Med ID
      Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons
      Aidong Yuan 1 , Takahiro Sasaki, Asok Kumar, Corrinne M Peterhoff, Mala V Rao, Ronald K Liem, Jean-Pierre Julien, Ralph A Nixon
      J Neurosci  32(25)  8501-8  2012

      Show Abstract
      Western Blotting22723690 22723690
      Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity.
      Jeong, Yongsu, et al.
      Development, 138: 531-41 (2011)  2011

      Show Abstract
      21205797 21205797
      Motor unit abnormalities in Dystonia musculorum mice.
      De Repentigny, Y; Ferrier, A; Ryan, SD; Sato, T; Kothary, R
      PloS one  6  e21093  2011

      Show Abstract
      21698255 21698255
      Viral induction of central nervous system innate immune responses.
      Rempel, JD; Quina, LA; Blakely-Gonzales, PK; Buchmeier, MJ; Gruol, DL
      Journal of virology  79  4369-81  2005

      Show Abstract
      15767437 15767437

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies