MAB411 Anti-Interferon-α2 Antibody, clone ST2541

MAB411
500 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H NEUT, ABA, WB, ELISA M Ascites Monoclonal Antibody
      Description
      Catalogue NumberMAB411
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Interferon-α2 Antibody, clone ST2541
      Alternate Names
      • Interferon alpha-2
      • IFN-alpha-2
      • Interferon alpha-A
      • LeIF A
      Background InformationInterferon alpha-2 (UniProt P01563; also known as IFN-alpha-2, Interferon alpha-A, LeIF A) is encoded by the IFNA2 (also known as IFNA2A, IFNA2B, IFNA2C) gene (Gene ID 3440) in human. Interferons (IFNs) are cytokines whose prouction and release by host cells are induced in the presence of pathogens (e.g. viruses, bacteria, parasites) and tumor cells. Originally named for their ability to interfere with viral replication, IFNs mediate the activate immune cells, such as natural killer cells and macrophages, and increase host defense by up-regulating antigen presentation by boosting the expression of major histocompatibility complex (MHC) antigens. More than twenty distinct IFN genes and proteins have been identified and classified into three main types. Type I IFNs (IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω) exert their function via binding IFN-α/β receptor (encoded by the IFNAR1 and IFNAR2 gene, respectively). IFN-γ is the only known type II IFN, it is released by type 1 T helper cells and binds IFN-γ receptor (encoded by the IFNGR1 and IFNGR2 gene, respectively). Type III IFNs signal through a receptor complex consisting of IL10R2 (CRF2-4) and IFNLR1 (CRF2-12).
      References
      Product Information
      FormatAscites
      PresentationLiquid, no preservatives
      Quality LevelMQ100
      Applications
      ApplicationDetect Interferon-α2 using this Anti-Interferon-α2 Antibody, clone ST254 validated for use in NEUT, WB, ELISA, Affinity binding.
      Key Applications
      • Neutralizing
      • Affinity Binding Assay
      • Western Blotting
      • ELISA
      Application NotesNeutralizing Analysis: A representative lot enhanced viral replication by neutralizing host-secreted IFN in human prostate cancer PC3 cultures infected with P/V-CPI(−) and P/V-CPI(−)-G3A at a low MOI (Gainey, M.D., et al. (2000). J. Virol. 82(19):9369-9380).
      Neutralizing Analysis: A representative lot neutralized human IFN-αA (IFN-α2) and IFN-αN (produced by Nalmalwa human Burkitt's lymphoma cells), but not IFN-α1, antiviral activity against Semliki Forest Virus in human WISH amniotic epithelial cell cultures (Shearer, M., et al. (1984). J. Immunol. 133(6):3096-3101).
      Affinity Binding Assay: A representative lot captured human IFN-α2, but not human IFN-α1 (Shearer, M., et al. (1984). J. Immunol. 133(6):3096-3101).
      ELISA Neutralizing Analysis: A representative lot was used as the detection antibody for the detection of human IFN-αN (produced by Nalmalwa human Burkitt's lymphoma cells) by sandwich ELISA (Shearer, M., et al. (1984). J. Immunol. 133(6):3096-3101).
      Western Blotting Analysis: A representative lot detected IFN-αA (IFN-α2) and IFN-αN (produced by Nalmalwa human Burkitt's lymphoma cells) under reducing condition by Western blotting (Shearer, M., et al. (1984). J. Immunol. 133(6):3096-3101).
      Biological Information
      ImmunogenHuman alpha-interferon.
      CloneST2541
      HostMouse
      SpecificityClone ST2541 neutralized human IFN-αA (IFN-α2) and IFN-αN (produced by Nalmalwa human Burkitt's lymphoma cells), but not IFN-α1, antiviral activity (Shearer, M., et al. (1984). J. Immunol. 133(6):3096-3101).
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IFNA2
      • IFNA2A
      • IFNA2B
      • IFNA2C
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01563 # Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
      SIZE: 188 amino acids; 21550 Da
      SUBCELLULAR LOCATION: Secreted.
      SIMILARITY: SwissProt: P01563 ## Belongs to the alpha/beta interferon family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -20°C for up to one year. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size500 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Interferon-α2 Antibody, clone ST2541 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Interferon-α2 Antibody, clone ST2541 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN a-INTERFERON MONOCLONAL ANTIBODY - 20360902036090
      MOUSE ANTI-HUMAN a-INTERFERON MONOCLONAL ANTIBODY - 20518612051861
      MOUSE ANTI-HUMAN a-INTERFERON MONOCLONAL ANTIBODY - 22024372202437
      MOUSE ANTI-HUMAN a-INTERFERON MONOCLONAL ANTIBODY - 22833352283335
      MOUSE ANTI-HUMAN a-INTERFERON MONOCLONAL ANTIBODY - 23263622326362
      MOUSE ANTI-HUMAN α-INTERFERON MONOCLONAL ANTIBODY - 23290452329045
      MOUSE ANTI-HUMAN α-INTERFERON -26042942604294
      MOUSE ANTI-HUMAN α-INTERFERON -26047592604759
      MOUSE ANTI-HUMAN α-INTERFERON -26087302608730
      MOUSE ANTI-HUMAN α-INTERFERON -26290122629012

      References

      Reference overviewPub Med ID
      HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly.
      Reed, JC; Molter, B; Geary, CD; McNevin, J; McElrath, J; Giri, S; Klein, KC; Lingappa, JR
      The Journal of cell biology  198  439-56  2012

      Show Abstract
      22851315 22851315
      Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms.
      Thielen, BK; McNevin, JP; McElrath, MJ; Hunt, BV; Klein, KC; Lingappa, JR
      The Journal of biological chemistry  285  27753-66  2010

      Show Abstract
      20615867 20615867
      A hyperfusogenic F protein enhances the oncolytic potency of a paramyxovirus simian virus 5 P/V mutant without compromising sensitivity to type I interferon.
      Gainey, MD; Manuse, MJ; Parks, GD
      Journal of virology  82  9369-80  2008

      Show Abstract Full Text Article
      18667520 18667520
      Monoclonal antibodies that distinguish between subspecies of human interferon-alpha and that detect interferon oligomers.
      Shearer, M, et al.
      J. Immunol., 133: 3096-101 (1984)  1984

      Show Abstract
      6491281 6491281

      Data Sheet

      Title
      MOUSE ANTI-HUMAN α-INTERFERON

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies