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428035 Anti-HOCl-Oxidized Low Density Lipoprotein Rabbit pAb

Anti-HOCl-Oxidized Low Density Lipoprotein, rabbit polyclonal, recognizes HOCl-LDL. Weakly cross-reacts with HNE-LDL. It is validated for use in ELISA and IHC (frozen and paraffin sections).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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428035
  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityHostAntibody Type
      A Broad Range Of SpeciesRbPolyclonal Antibody
      Description
      OverviewRecognizes HOCl-LDL. Weakly cross-reacts with HNE-LDL.
      Catalogue Number428035
      Brand Family Calbiochem®
      References
      ReferencesLau, B.H. 2001. J. Nutrition 131, 985s.
      Product Information
      FormLyophilized
      FormulationUndiluted serum.
      PreservativeNone
      Quality LevelMQ100
      Applications
      Key Applications Enzyme-Linked Immunosorbent Assay
      Frozen Sections
      Paraffin Sections
      Application NotesELISA (1:400-1:4000)
      Frozen Sections (<1:400)
      Paraffin Sections (<1:400)
      Application CommentsDoes not cross-react with unmodified LDL. Weakly cross-reacts with HNE-LDL. Variables associated with assay conditions will dictate the optimal working dilution.
      Biological Information
      Immunogenhuman hypochlorite-modified low density lipoprotein (LDL)
      ImmunogenHuman
      HostRabbit
      IsotypeIgG
      Species Reactivity
      • A Broad Range Of Species
      Antibody TypePolyclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsReconstitute with 100 µl sterile distilled water. Following reconstitution, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      428035

      Documentation

      Anti-HOCl-Oxidized Low Density Lipoprotein Rabbit pAb SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-HOCl-Oxidized Low Density Lipoprotein Rabbit pAb Certificates of Analysis

      TitleLot Number
      428035

      References

      Reference overview
      Lau, B.H. 2001. J. Nutrition 131, 985s.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-August-2007 RFH
      ApplicationELISA (1:400-1:4000)
      Frozen Sections (<1:400)
      Paraffin Sections (<1:400)
      DescriptionRabbit polyclonal antibody supplied as lyophilized undiluted serum. Recognizes HOCL-oxidized low density lipoprotein (LDL).
      BackgroundOxidation of LDL plays an important role in the initiation and progression of atherosclerosis. Arterial macrophages take up oxidized low-density lipoproteins (OxLDL), leading to cellular accumulation of cholesterol and oxysterols. OxLDL, but not native LDL, promotes vascular dysfunction by exerting direct cytotoxicity toward endothelial cells, by increasing chemotactic properties for monocytes, by transforming macrophages to foam cells via scavenger-receptors and by enhancing the proliferation of various cell types, e.g., endothelial cells, monocytes and smooth muscle cells; all of these events are recognized as contributing to atherogenesis.
      HostRabbit
      Immunogen speciesHuman
      Immunogenhuman hypochlorite-modified low density lipoprotein (LDL)
      IsotypeIgG
      Speciesa broad range of species
      FormLyophilized
      FormulationUndiluted serum.
      PreservativeNone
      CommentsDoes not cross-react with unmodified LDL. Weakly cross-reacts with HNE-LDL. Variables associated with assay conditions will dictate the optimal working dilution.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsReconstitute with 100 µl sterile distilled water. Following reconstitution, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesLau, B.H. 2001. J. Nutrition 131, 985s.