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ABS1028 Anti-GPR56, C-terminal Antibody

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ABS1028
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IP, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABS1028
      DescriptionAnti-GPR56, C-terminal Antibody
      Alternate Names
      • GPR56 seven-transmembrane subunit
      • GPR56 7TM
      • GPR56 subunit beta
      • GPR56 CT
      • GPR56©
      • TM7XN1
      Background InformationG-protein coupled receptor 56 (GPR56) is a ubiquitous adhesion receptor, which belongs to the G-protein coupled receptor 2 family and LN-TM7 subfamily. It is abundantly expressed in the in thyroid gland, brain, heart, and various tumor cells. Previous studies have suggested that GPR56 may inhibit the progression and metastasis of melanomas by interaction with extracellular-matrix proteins, such as Tissue Transglutaminase. GPR56 also plays a role in regulating VEGF production and angiogenesis via a PKCα-mediated pathway. GPR56 also plays a critical role in the development of the frontal cortex; previous studies have reported that mutations in GPR56 result in disorganized cortical lamination, which is most pronounced in the frontal cortex. This condition is known as bilateral frontoparietal polymicrogyria or BFPP.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-GPR56, C-terminal Antibody is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry for the detection of GPR56, C-terminal.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      Application NotesImmunoprecipitation Analysis: A representative lot of this antibody immunoprecipated GPR56 from rat kidney cell lysate and visualized through western blot (Paavola, K., et al. (2011). J. Biol. Chem. 2011, 286:28914-28921.)
      Western Blot Analysis: A representative lot of this antibody detected GPR56 from rat kidney cell lysate (Paavola, K., et al. (2011). J. Biol. Chem. 2011, 286:28914-28921.)
      Immunocytochemistry Analysis: A representative lot of this antibody detected GPR56 from transfected HEK293 cells (Paavola, K., et al. (2011). J. Biol. Chem. 2011, 286:28914-28921.)
      Biological Information
      Immunogenlinear peptide corresponding to the C-terminus of Mouse GPR56.
      EpitopeC-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteHuman, Rat. Predicted to react with Mouse based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GPR56
      • TM7LN4
      • TM7XN1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~ 120 kDa observed
      This receptor is heavily glycosylated in cells, and thus the apparent molecular mass of the full-length receptor in most cell types is around 90-120 kDa. Moreover, this receptor is prone to extensive post-translational processing and proteolysis, and thus depending on the cell type the most prominent immunoreactive bands on Western blot are usually around 45 kDa, 25 kDa and/or 15 kDa in size
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Hela cell lysate.

      Western Blotting Analysis: 1 µg/ml of this antibody detected GPR56 in 10 µg of Hela cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      ABS1028 04053252993084

      Documentation

      Anti-GPR56, C-terminal Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-GPR56, C-terminal Antibody Certificates of Analysis

      TitleLot Number
      Anti-GPR56, C-terminal - Q2452353 Q2452353
      Anti-GPR56, C-terminal Polyclonal Antibody 2920714
      Anti-GPR56, C-terminal Polyclonal Antibody 3156025
      Anti-GPR56, C-terminal Polyclonal Antibody 3022939

      References

      Reference overviewPub Med ID
      The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity.
      Paavola, Kevin J, et al.
      J. Biol. Chem., 286: 28914-21 (2011)  2011

      Show Abstract
      21708946 21708946

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies