AB10305 Anti-FXR-B Antibody

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AB10305
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB10305
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-FXR-B Antibody
      Alternate Names
      • Bile acid receptor
      • Farnesoid X-activated receptor
      • Farnesol receptor HRR-1
      • Nuclear receptor subfamily 1 group H member 4
      • Retinoid X receptor-interacting protein 14
      • RXR-interacting protein 14
      Background InformationThe farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is known to play a key role in bile acid homeostasis. It does through the regulation of key genes involved in bile acid synthesis, metabolism and transport.
      References
      Product Information
      FormatSerum
      PresentationRabbit polyclonal antiserum with 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect FXR-B using this Anti-FXR-B Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesSuggested dilutions:
      Western Blotting: 1:5,000
      Biological Information
      ImmunogenRecombinant human FXR-B
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NR1H4
      • BAR
      • FXR
      • HRR1
      • RIP14
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q96RI1 # Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus.
      SIZE: 486 amino acids; 55914 Da
      SUBUNIT: Heterodimer of NR1H4 and RXR. Interacts with CARM1 and SMARD1.
      SUBCELLULAR LOCATION: Nucleus (Probable).
      SIMILARITY: SwissProt: Q96RI1 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain.
      Molecular Weight~56 kDa observed.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting of recombinant human FXR-B.

      Western Blotting Analysis: A 1:5,000 dilution of this rabbit polyclonal antiserum detected recombinant human FXR-B.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-FXR-B Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-FXR-B Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-FXR-B - 34635633463563
      RABBIT ANTI-FXR-B -27162812716281

      References

      Reference overviewPub Med ID
      LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR.
      Okuwaki, Masae, et al.
      Pharm. Res., 24: 390-8 (2007)  2007

      Show Abstract
      17177110 17177110
      Analysis of bile acid-induced regulation of FXR target genes in human liver slices
      Jung, Diana, et al
      Liver Int, 27:137-44 (2007)  2007

      17241392 17241392
      The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression
      Swales, Karen E, et al
      Cancer Res, 66:10120-6 (2006)  2006

      17047076 17047076

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies