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AB3127 Anti-FLT-4 Antibody

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AB3127
50 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3127
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-FLT-4 Antibody
      Alternate Names
      • VEGF Receptor-3
      References
      Product Information
      FormatAffinity Purified
      PresentationLiquid in PBS, containing 0.1% BSA. Affinity purified immunoglobulin.
      Quality LevelMQ100
      Applications
      ApplicationDetect FLT-4 using this Anti-FLT-4 Antibody validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-10 μg/mL using ECL. The antibodies detected ~140 kDa band in rat liver extracts.

      ELISA: 1:10,000-1:100,000, using 50-100ng of control peptide/well.

      Optimal working dilutions must be determined by end user.
      Biological Information
      Immunogen20 amino acid peptide sequence within the cytoplasmic, C-terminus of mouse Flt-4
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes mouse Flt-4 (mouse 1363-aa and human 1298-aa) a receptor protein tyrosine kinase. It is type 1 membrane protein, a receptor for VEGF-C and is expressed in adult lung, and liver, and in fetal liver, brain, intestine, and placenta. Flt-4 is also known as vascular endothelial growth factor receptor 3 (VEGFR3).

      SPECIES REACTIVITIES: The peptide sequence used is relatively conserved in rat (85%) and human (73%) Flt-4/VEGFR3. No significant sequence homology is seen with VEGFR1, VEGFR2, or other tyrosine kinases. Antibody crossreactivity in other species is not established.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FLT4
      • PCL
      • VEGFR-3
      • FLT41
      • VEGFR3
      • EC 2.7.10.1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P35916 # Receptor for VEGFC. Has a tyrosine-protein kinase activity.
      SIZE: 1298 amino acids; 145599 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Placenta, lung, heart, and kidney, does not seem to be expressed in pancreas and brain.
      DISEASE: SwissProt: P35916 # Defects in FLT4 are the cause of hereditary lymphedema I [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Hereditary lymphedema I shows autosomal dominant inheritance and is characterized by onset usually at birth. & Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10/% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.
      SIMILARITY: SwissProt: P35916 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 7 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze and thaw.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-FLT-4 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-FLT-4 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-FLT-4 - 3706624 3706624
      RABBIT ANTI-FLT-4 AFFINITY-PURIFIED -2510129 2510129
      RABBIT ANTI-FLT-4 AFFINITY-PURIFIED -2544302 2544302
      RABBIT ANTI-FLT-4 AFFINITY-PURIFIED -2817730 2817730
      RABBIT ANTI-FLT-4 AFFINITY-PURIFIED POLYCLONAL ANTIBODY 2962963
      RABBIT ANTI-FLT-4 AFFINITY-PURIFIED POLYCLONAL ANTIBODY 3045782
      RABBIT ANTI-FLT-4 AFFINITY-PURIFIED POLYCLONAL ANTIBODY - 2074018 2074018

      References

      Reference overviewPub Med ID
      Molecular cloning of murine FLT and FLT4.
      Finnerty, H, et al.
      Oncogene, 8: 2293-8 (1993)  1993

      Show Abstract
      8393164 8393164
      FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter
      Aprelikova, O, et al
      Cancer Res, 52:746-748 (1992)  1992

      1310071 1310071

      Data Sheet

      Title
      RABBIT ANTI-FLT-4 AFFINITY-PURIFIED

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      Product Families

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies