AB1975 Anti-Enkephalin, Met Antibody

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AB1975
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      R IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB1975
      ReplacesAB5026
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Enkephalin, Met Antibody
      Background InformationMet Enkephalin is an endogenous opioid peptide neurotransmitter found naturally in the brains of many animals, including humans. Methionine enkephalin (Met Enkephalin) is a pentapeptide that appears to enhance immune function at low doses and suppress at high doses. This molecule acts in the central nervous, neuroendocrine, and immune systems. During development of the brain Met Enkephalin is thought to act as a growth factor. Met Enkephalin may be capable of enhancing immune function in cancer or AIDS patients.
      References
      Product Information
      FormatSerum
      Control
      • Tested on rat brain/coronal section
      PresentationSerum in 0.05% Sodium Azide
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Enkephalin, Met Antibody is validated for use in IH for the detection of Enkephalin.
      Key Applications
      • Immunohistochemistry
      Applications Not Recommended
      • Western Blotting
      Application NotesImmunohistochemistry (with immunoperoxidase detection *): 48 hour incubation, 4°C.

      Spinal cord nerve fibers (rat): 1:2,000-1:4,000.

      Immunofluorescence*: overnight incubation, +2-8°C

      Duodenum endocrine cells & nerve fibers (pig): 1:2,000

      Ileum endocrine cells & nerve fibers μguinea pig): 1:4,000.

      *fixative-any cross-linking reagent

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenMet-enkephalin, Hemocyanin conjugate.
      HostRabbit
      SpecificityMet-enkephalin
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • PENK
      • proenkephalin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01210 # Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.
      SIZE: 267 amino acids; 30787 Da
      SUBCELLULAR LOCATION: Secreted.
      PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
      SIMILARITY: SwissProt: P01210 ## Belongs to the opioid neuropeptide precursor family.
      Molecular Weight0.6 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Enkephalin, Met Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Enkephalin, Met Antibody Certificates of Analysis

      TitleLot Number
      Anti-Met Enkephalin - 24244972424497
      Anti-Met Enkephalin - 20069232006923
      Anti-Met Enkephalin - 21726942172694
      Anti-Met Enkephalin - 25124202512420
      Anti-Met Enkephalin - 32887433288743
      Anti-Met Enkephalin - LV1454106LV1454106
      Anti-Met Enkephalin - LV1758405LV1758405
      Anti-Met Enkephalin -26975082697508
      Anti-Met Enkephalin -27198862719886
      Anti-Met Enkephalin -27390312739031

      References

      Reference overviewPub Med ID
      Phenotypic diversity and expression of GABAergic inhibitory interneurons during postnatal development in lumbar spinal cord of glutamic acid decarboxylase 67-green fluorescent protein mice.
      Dougherty, KJ; Sawchuk, MA; Hochman, S
      Neuroscience  163  909-19  2009

      Show Abstract Full Text Article
      19560523 19560523
      The presence and absence of prosencephalic cell groups relaying striatal information to the medial and lateral thalamus in tenrec.
      Heinz Künzle
      Journal of anatomy  212  2008

      Show Abstract Full Text Article
      18510507 18510507

      Related Products & Applications

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      Catalog Number Description  
      AB5026 Anti-Enkephalin Antibody, Met Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies