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AB1253 Anti-Cytochrome P450 Enzyme CYP3A1 Antibody

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AB1253
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHC, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1253
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cytochrome P450 Enzyme CYP3A1 Antibody
      References
      Product Information
      FormatSerum
      PresentationRabbit antiserum. Liquid. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Cytochrome P450 Enzyme CYP3A1 Antibody is validated for use in IH, WB for the detection of Cytochrome P450 Enzyme CYP3A1.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot

      Immunohistochemistry on formaldehyde treated sections.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide
      HostRabbit
      SpecificityReacts with rat cytochrome P450 enzyme CYP3A1 in hepatic microsomal fraction. No cross-reactivity with other cytochrome P450 enzymes including CYP3A2.
      Species Reactivity
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Cytochrome P450 Enzyme CYP3A1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Cytochrome P450 Enzyme CYP3A1 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 POLYCLONAL ANTIBODY 2950604
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 POLYCLONAL ANTIBODY - 2343544 2343544
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 POLYCLONAL ANTIBODY - 2395644 2395644
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 POLYCLONAL ANTIBODY - 2435027 2435027
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 - 3317056 3317056
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 - 3695886 3695886
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 -2742716 2742716
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 -3164866 3164866
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 POLYCLONAL ANTIBODY 3082826
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1 POLYCLONAL ANTIBODY - 2168244 2168244

      References

      Reference overviewPub Med ID
      Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells.
      Martin, P; Riley, R; Thompson, P; Williams, D; Back, D; Owen, A
      Acta pharmacologica Sinica  31  51-65  2010

      Show Abstract
      20048746 20048746
      Expression of CYP3A23/1, CYP3A2, PXR, CAR and HNF4alpha in large-for-gestational-age neonatal rats.
      Shaoqing Ni, Xiumin Wang, Jue Wang, Su Zeng, Zhengyan Zhao, Shaoqing Ni, Xiumin Wang, Jue Wang, Su Zeng, Zhengyan Zhao
      Die Pharmazie  64  252-7  2009

      Show Abstract
      19435144 19435144
      Temporal evaluation of CYP mRNA in mice administered with prototypical P450 inducers: comparison with conventional protein/enzyme methods.
      Er-Jia Wang,George Mandakas,Jairam Palamanda,Xinjie Lin,Pramila Kumari,Inhou Chu,Anthony Soares,Roger J Smith,Ronald D Snyder,Yi-Zhong Gu
      Drug and chemical toxicology  31  2008

      Show Abstract
      18850359 18850359
      Effects of intrauterine undernutrition on the expression of CYP3A23/3A1, PXR, CAR and HNF4alpha in neonate rats.
      Shaoqing Ni, Xiumin Wang, Jue Wang, Sijie Lu, Su Zeng, Zhengyan Zhao, Lushan Yu, Shuqing Chen, Shaoqing Ni, Xiumin Wang, Jue Wang, Sijie Lu, Su Zeng, Zhengyan Zhao, Lushan Yu, Shuqing Chen
      Biopharmaceutics drug disposition  29  501-10  2008

      Show Abstract
      19058292 19058292
      Age-specific pulmonary cytochrome P-450 3A1 expression in postnatal and adult rats.
      Day, KC; Plopper, CG; Fanucchi, MV
      American journal of physiology. Lung cellular and molecular physiology  291  L75-83  2006

      Show Abstract
      16461430 16461430
      P450 induction alters paclitaxel pharmacokinetics and tissue distribution with multiple dosing.
      Daniel L Gustafson, Michael E Long, Erica L Bradshaw, Andrea L Merz, Patrick J Kerzic
      Cancer chemotherapy and pharmacology  56  248-54  2005

      Show Abstract
      15856231 15856231
      Alterations in P-glycoprotein expression in mouse tissues by doxorubicin: implications for pharmacokinetics in multiple dosing regimens.
      D L Gustafson, M E Long
      Chemico-biological interactions  138  43-57  2001

      Show Abstract
      11640914 11640914
      Cytochrome P-450 3A4: regulation and role in drug metabolism
      Guengerich, F P
      Annu Rev Pharmacol Toxicol, 39:1-17 (1999)  1999

      10331074 10331074
      Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues.
      Debri, K, et al.
      Biochem. Pharmacol., 50: 2047-56 (1995)  1995

      Show Abstract
      8849332 8849332

      Data Sheet

      Title
      RABBIT ANTI-RAT CYTOCHROME P450 ENZYME CYP3A1