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AB1258 Anti-Cytochrome P450 Enzyme CYP1A1 Antibody

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AB1258
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1258
      ReplacesMAB3522
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cytochrome P450 Enzyme CYP1A1 Antibody
      References
      Product Information
      FormatSerum
      PresentationRabbit antiserum. Liquid, no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Cytochrome P450 Enzyme CYP1A1 Antibody detects level of Cytochrome P450 Enzyme CYP1A1 & has been published & validated for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot

      Immunohistochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide
      HostRabbit
      SpecificityReacts with human cytochrome P450 CYP1A1 in human placental microsomal fraction and to recombinant human CYP1A1.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
      Gene Symbol
      • CYP1A1
      • CP11
      • P1-450
      • CYPIA1
      • P450-C
      • CYP1
      • P450DX
      • P450-P1
      • AHRR
      • AHH
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04798 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
      SIZE: 512 amino acids; 58165 Da
      SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
      TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
      SIMILARITY: SwissProt: P04798 ## Belongs to the cytochrome P450 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Cytochrome P450 Enzyme CYP1A1 Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Cytochrome P450 Enzyme CYP1A1 Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 POLYCLONAL ANTIBODY - 2119729 2119729
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 POLYCLONAL ANTIBODY - 2411809 2411809
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2681213 2681213
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2695211 2695211
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2855526 2855526
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2858474 2858474
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 -2891085 2891085
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 POLYCLONAL ANTIBODY 3032744
      RABBIT ANTI-HUMAN CYTOCHROME P450 CYP1A1 POLYCLONAL ANTIBODY - 2168240 2168240

      References

      Reference overviewApplicationSpeciesPub Med ID
      A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth.
      Yin, XF; Chen, J; Mao, W; Wang, YH; Chen, MH
      Journal of experimental & clinical cancer research : CR  31  46  2012

      Show Abstract
      22592002 22592002
      Aryl hydrocarbon receptor pathway activation enhances gastric cancer cell invasiveness likely through a c-Jun-dependent induction of matrix metalloproteinase-9.
      Peng, TL; Chen, J; Mao, W; Song, X; Chen, MH
      BMC cell biology  10  27  2009

      Show Abstract Full Text Article
      19371443 19371443
      Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium.
      Singh, MN; Stringfellow, HF; Taylor, SE; Ashton, KM; Ahmad, M; Abdo, KR; El-Agnaf, OM; Martin-Hirsch, PL; Martin, FL
      Molecular human reproduction  14  655-63  2008

      Show Abstract
      ImmunohistochemistryHuman18849443 18849443
      Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.
      Hakkola, J, et al.
      Biochem. Pharmacol., 51: 403-11 (1996)  1996

      8619884 8619884

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies