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MABN486 Anti-Co-Rest/RCOR1 Antibody, clone K72/8

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MABN486
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IHC, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN486
      DescriptionAnti-Co-Rest/RCOR1 Antibody, clone K72/8
      Alternate Names
      • REST corepressor 1
      • Protein CoREST
      Background InformationREST corepressor 1(RCOR1, CoREST) is an essential component of the BHC corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. RCOR1 also promotes the demethylase activity of KDM1A on core histones and nucleosomal substrates and plays a central role in demethylation of Lys-4 of histone H3. Furthermore, RCOR1 is a component of a RCOR/GFI/KDM1A/HDAC complex that suppresses a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. RCOR1 is ubiquitously expressed and is primarily found in the nucleus, but is partially translocated into the cytoplasm upon HSV-1 infection.
      References
      Product Information
      FormatPurified
      Control
      • Jurkat cell lysate
      PresentationPurified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Co-Rest/RCOR1 Antibody, clone K72/8 is a highly specific mouse monoclonal antibody, that targets CoRest & has been tested in western blotting, IHC & ICC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Co-Rest/RCOR1 in human stomach tissue.
      Immunocytochemistry Analysis: A representative lot detected Co-Rest/RCOR1 in COS-1 cells expressing Myc-tagged Co-Rest. (Prof. J. Trimmer, University of California, Davis.).
      Biological Information
      ImmunogenRecombinant protein corresponding to human Co-Rest/RCOR1.
      Cloneclone K72/8
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody may cross react with human RCOR3 based upon 70% sequence homology.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RCOR1
      • KIAA0071
      • RCOR
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 65 kDa observed. The calculated molecular weight is 53 kDa, however Co-Rest/RCOR1 has been shown as a ~65-70 kDa band in western blots (You, A., et al. (2001). National Academy of Sciences. 98(4):1454-1458)(Min, G. L., et al. (2005). Nature. 437:432-435).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 1.0 µg/mL of this antibody detected Co-Rest/RCOR1 in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies