AB5370P Anti-Capsaicin Receptor Antibody, CT

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AB5370P
20 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R IHC Rb Affinity Purified Polyclonal Antibody
      Description
      Catalogue NumberAB5370P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Capsaicin Receptor Antibody, CT
      Alternate Names
      • Vanilloid Receptor 1
      • VR1
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Lyophilized. Contains no preservative. Reconstitute with 20 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Capsaicin Receptor Antibody, C-terminus is an antibody against Capsaicin Receptor for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1-2 μg/mL.

      The antibody reacts well with tissue from the rat dorsal root ganglia.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
      EpitopeC-terminus
      HostRabbit
      SpecificityCapsaicin Receptor (Vanilloid Receptor 1, VR1).
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCapsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
      Gene Symbol
      • TRPV1
      • VR1
      • OTRPC1
      • DKFZp434K0220
      • TrpV1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
      SIZE: 839 amino acids; 94938 Da
      SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
      TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).DOMAIN:SwissProt: Q8NER1 The association domain (AD) is necessary for self- association (By similarity).
      PTM: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity).
      SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
      MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
      Packaging Information
      Material Size20 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Capsaicin Receptor Antibody, CT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Capsaicin Receptor Antibody, CT Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) - 34219503421950
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY2937876
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY2935539
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY2967783
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 20487532048753
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 21104572110457
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1, TRPV1) AFFINITY PURIFIED, POLYCLONAL ANTIBODY - 22816302281630
      RABBIT ANTI-CAPSAICIN RECEPTOR -26394462639446

      References

      Reference overviewApplicationSpeciesPub Med ID
      Expression and distribution of vannilloid receptor 1 (TRPV1) in the adult rat brain
      Toth, A. et al.
      Molecular Brain Research, 135:162-168 (2005)  2005

      Immunoblotting (Western), Immunohistochemistry (Tissue)Rat15857679 15857679

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      Alternative Format

      Catalog Number Description  
      AB5370 Anti-Capsaicin Receptor Antibody, CT Show Pricing & Availability

      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies