AB5370 Anti-Capsaicin Receptor Antibody, CT

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AB5370
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB5370
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Capsaicin Receptor Antibody, CT
      Alternate Names
      • Vanilloid Receptor 1
      • VR1
      References
      Product Information
      FormatSerum
      PresentationSerum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
      Quality LevelMQ100
      Applications
      ApplicationDetect Capsaicin Receptor using this Anti-Capsaicin Receptor Antibody, C-terminus validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:2,000. The antibody reacts well with tissue from the rat dorsal root ganglia.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenA 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
      EpitopeC-terminus
      HostRabbit
      SpecificityCapsaicin Receptor (Vanilloid Receptor 1, VR1).
      Species Reactivity
      • Human
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCapsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
      Gene Symbol
      • TRPV1
      • VR1
      • OTRPC1
      • DKFZp434K0220
      • TrpV1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
      SIZE: 839 amino acids; 94938 Da
      SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
      TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).DOMAIN:SwissProt: Q8NER1 The association domain (AD) is necessary for self- association (By similarity).
      PTM: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity).
      SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
      MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Capsaicin Receptor Antibody, CT SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Capsaicin Receptor Antibody, CT Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY - 21459212145921
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY - 24333152433315
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) - 31736133173613
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) - 31738383173838
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY3031332
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY - 19922631992263
      RABBIT ANTI-CAPSAICIN RECEPTOR -28041972804197

      References

      Reference overviewApplicationSpeciesPub Med ID
      Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone.
      Koen Van Crombruggen,L Van Nassauw,L Derycke,J-P Timmermans,G Holtappels,D Hall,C Bachert
      Naunyn-Schmiedeberg's archives of pharmacology  383  2011

      Show Abstract
      21523557 21523557
      Parvalbumin and TRPV1 receptor expression in dorsal root ganglion neurons after acute peripheral inflammation.
      G Zacharová, J Palecek, G Zacharová, J Palecek, G Zacharová, J Palecek
      Physiological research / Academia Scientiarum Bohemoslovaca  58  305-9  2009

      Show Abstract
      19397388 19397388
      TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
      De Schepper, HU; De Man, JG; Ruyssers, NE; Deiteren, A; Van Nassauw, L; Timmermans, JP; Martinet, W; Herman, AG; Pelckmans, PA; De Winter, BY
      American journal of physiology. Gastrointestinal and liver physiology  294  G245-53  2008

      Show Abstract
      17991707 17991707
      TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats.
      De Schepper, HU; De Winter, BY; Van Nassauw, L; Timmermans, JP; Herman, AG; Pelckmans, PA; De Man, JG
      The Journal of physiology  586  5247-58  2008

      Show Abstract Full Text Article
      18755744 18755744
      Expression and distribution of vannilloid receptor 1 (TRPV1) in the adult rat brain
      Toth, A. et al.
      Molecular Brain Research, 135:162-168 (2005)  2005

      Immunoblotting (Western), Immunohistochemistry (Tissue)Rat15857679 15857679
      Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.
      Wallace K MacNaughton, Marja D Van Sickle, Catherine M Keenan, Kelly Cushing, Ken Mackie, Keith A Sharkey
      American journal of physiology. Gastrointestinal and liver physiology  286  G863-71  2004

      Show Abstract
      14701723 14701723

      Data Sheet

      Title
      RABBIT ANTI-CAPSAICIN RECEPTOR (VANILLOID RECEPTOR 1, VR1) POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies