AB9554 Anti-Capsaicin Receptor Antibody

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AB9554
50 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M IHC Rb Serum Polyclonal Antibody
      Description
      Catalogue NumberAB9554
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Capsaicin Receptor Antibody
      Alternate Names
      • Vanilloid Receptor
      • VR1
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Liquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Capsaicin Receptor Antibody is an antibody against Capsaicin Receptor for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:500-1:1,000 on mouse DRG tissued fixed with 2% paraformaldehyde.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the C-terminal of mouse VR1.
      HostRabbit
      SpecificityRecognizes Capsaicin Receptor (VR1, Vallinoid Receptor 1, TRPV1).
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCapsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
      Gene Symbol
      • TRPV1
      • VR1
      • OTRPC1
      • TrpV1
      • DKFZp434K0220
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
      SIZE: 839 amino acids; 94938 Da
      SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
      TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).DOMAIN:SwissProt: Q8NER1 The association domain (AD) is necessary for self- association (By similarity).
      PTM: Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity (By similarity).
      SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. & Contains 3 ANK repeats.
      MISCELLANEOUS: Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Capsaicin Receptor Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Capsaicin Receptor Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY - 21155372115537
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY - 21179672117967
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) - 32886623288662
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) -26613142661314
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY3142458
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY - 19763851976385
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY - 20321832032183
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY - 22013722201372
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY - 22315922231592
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1) POLYCLONAL ANTIBODY - 22341132234113

      Data Sheet

      Title
      RABBIT ANTI- CAPSAICIN RECEPTOR (VR1)

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies