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MABS1251 Anti-CYP11B2 Antibody, clone 41-17B

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MABS1251
100 μg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, IFMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1251
      DescriptionAnti-CYP11B2 Antibody, clone 41-17B
      Alternate Names
      • Cytochrome P450 11B2, mitochondrial
      • CYP11B2
      • Aldosterone synthase
      • ALDOS
      • Aldosterone-synthesizing enzyme
      • CYPXIB2
      • Cytochrome P-450Aldo
      • Cytochrome P-450C18
      • Steroid 18-hydroxylase
      Background InformationCytochrome P450 11B2, mitochondrial (EC1.14.15.4, EC1.14.15.5; UniProt P19099; also known as ALDOS, Aldosterone synthase, Aldosterone-synthesizing enzyme, CYPXIB2, Cytochrome P-450Aldo, Cytochrome P-450C18, Cytochrome P450 subfamily XIB polypeptide 2, Steroid 11-beta-monooxygenase, Steroid 11-beta/18-hydroxylase, Mitochondrial cytochrome P450 family 11 subfamily B polypeptide 2) is encoded by the CYP11B2 (Also known as CPN2, CYP11B, CYP11BL, P450C18) gene in human (Gene ID 1585). CYP11B2 protein is a member of the cytochrome P450 superfamily of monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP11B2 protein is localized to the mitochondrial inner membrane and exhibits steroid 18-hydroxylase activity and steroid 11 beta-hydroxylase activity. CYP11B2 gene mutations are known causes of corticosterone methyl oxidase 1 (CMO-1) deficiency, an autosomal recessive disorder of aldosterone biosynthesis.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CYP11B2 Antibody, clone 41-17B is an antibody against CYP11B2 for use in Western Blotting, Immunohistochemistry, Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: A representative lot detected CYP11B2 in normal adrenal glands (Gomez-Sanchez, C.E., et al. (2014). Mol. Cell Endocrinology. 383:111-117).
      Immunofluorescence Analysis: A representative lot detected CYP11B2 in normal adrenal glands (Gomez-Sanchez, C.E., et al. (2014). Mol. Cell Endocrinology. 383:111-117).
      Biological Information
      ImmunogenChicken serum albumin-conjugated linear peptide corresponding to human CYP11B2 near the N-terminus.
      EpitopeNear N-terminus
      Clone41-17B
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Mouse based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CYP11B2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~57 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in hCYP11B2-GFP-expressing HEK293 cell lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected CYP11B2 in 10 µg of hCYP11B2-GFP-expressing HEK293 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-CYP11B2 Antibody, clone 41-17B SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CYP11B2 Antibody, clone 41-17B Certificates of Analysis

      TitleLot Number
      Anti-CYP11B2, clone 41-17B - 2914880 2914880
      Anti-CYP11B2, clone 41-17B - 3235651 3235651
      Anti-CYP11B2, clone 41-17B - 3432498 3432498
      Anti-CYP11B2, clone 41-17B - 3547780 3547780
      Anti-CYP11B2, clone 41-17B - 3639188 3639188
      Anti-CYP11B2, clone 41-17B - 3729954 3729954
      Anti-CYP11B2, clone 41-17B -2782057 2782057
      Anti-CYP11B2, clone 41-17B -2849480 2849480
      Anti-CYP11B2, clone 41-17B -2851788 2851788
      Anti-CYP11B2, clone 41-17B -2854632 2854632

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage. (EMD)