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CBL555 Anti-CD34 Class III Antibody, clone 581

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CBL555
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberCBL555
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD34 Class III Antibody, clone 581
      References
      Product Information
      FormatPurified
      PresentationProtein G affinity chromatography. The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CD34 Antibody, Class III, clone 581 is validated for use in FC for the detection of CD34 Class III.
      Key Applications
      • Flow Cytometry
      Application NotesStudy of the Class III CD34 epitope by FACS

      Optimal working dilutions must be determined by the end user.
      Biological Information
      Clone581
      HostMouse
      SpecificityClone 581 reacts with the class III CD34 epitope is resistant to neuraminidase, chymopapain and glycoprotease.

      The antibody reacts with a single-chain 105-120 kDa heavily O-glycosylated transmembrane glycoprotein which is expressed on haematopoietic progenitor cells, vascular endothelium and some tissue fibroblasts. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. CD34 may also play a role in the adhesion of specific antigens to endothelium.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryCD34 is a monomeric cell surface antigen with a molecular mass of approximately 110 kD that is selectively expressed on human hematopoietic progenitor cells.[supplied by OMIM]
      Gene Symbol
      • CD34
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P28906 # Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
      SIZE: 385 amino acids; 40716 Da
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.
      DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells.
      PTM: Highly glycosylated. & Phosphorylated on serine residues by PKC.
      DISEASE:SwissProt: P28906 # Abnormal CD34 expression in leukemogenesis.
      SIMILARITY: SwissProt: P28906 ## Belongs to the CD34 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in the United States.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsFor use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-CD34 Class III Antibody, clone 581 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-CD34 Class III Antibody, clone 581 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-HUMAN CD34 TYPE III MONOCLONAL ANTIBODY 3046671
      MOUSE ANTI-HUMAN CD34 TYPE III MONOCLONAL ANTIBODY - 2411899 2411899
      MOUSE ANTI-HUMAN CD34 TYPE III MONOCLONAL ANTIBODY -2733574 2733574

      References

      Reference overviewPub Med ID
      Co-localization of angiotensin-converting enzyme 2-, octomer-4- and CD34-positive cells in rabbit atherosclerotic plaques.
      Anthony Zulli, Sudarshan Rai, Brian F Buxton, Louise M Burrell, David L Hare
      Experimental physiology  93  564-9  2008

      Show Abstract
      18192339 18192339
      Positive selection of bone marrow-derived CD34 positive cells for possible stem cell transplantation.
      Egeland, T, et al.
      Transplant. Proc., 25: 1261-3 (1993)  1993

      7680152 7680152

      Data Sheet

      Title
      Anti-CD34 Class III, clone 581 - Data Sheet

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies