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AB5694-I-100UG Anti-ATH 5

AB5694-I-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberAB5694-I-100UG
      DescriptionAnti-ATH 5
      Alternate Names
      • Protein atonal homolog 7
      • Class A basic helix-loop-helix protein 13
      • bHLHa13
      • Helix-loop-helix protein hATH-5
      Background InformationProtein atonal homolog 7 (UniProt: Q8N100; also known as Class A basic helix-loop-helix protein 13, bHLHa13, Helix-loop-helix protein hATH-5, hATH5) is encoded by the ATOH7 (also known as ATH5, BHLHA13) gene (Gene ID: 220202) in human. ATH5 is a basic helix-loop-helix (bHLH) transcription factor with one bHLH domain (aa 40-92). It is involved in the differentiation of retinal ganglion cells and plays a central role in retinal ganglion cell and optic nerve formation. Overexpression of ATH5 among neurogenic progenitors is shown to significantly enhance the production of retinal ganglionic cells at the expense of reducing the progenitor pool. Higher levels are also reported to accelerate cell cycle progression from S to M phase and promote cell cycle exit. Mutations in ATOH7 gene are known to cause Persistent hyperplastic primary vitreous that is characterized by developmental eye malformation associated with microphthalmia, cataract, glaucoma, and congenital retinal non-attachment. (Ref.: Brown, NL et al., (2002). Mamm. Genome. 13(2); 95-101; Zhang, XM et al., (2018). Sci. Rep. 8; Article number: 6823).
      References
      Product Information
      FormatPurified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-ATH 5, Cat. No. AB5694-I, is a highly specific rabbit polyclonal antibody that targets Protein atonal homolog 7 and has been tested for use in Immunocytochemistry and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a representative lot detected ATH 5 in SH-SY5Y cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 19 amino acids from within the bHLH domain.
      Epitopedomain of:
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityAnti-ATH 5 is a rabbit polyclonal antibody that detects Protein atonal homolog 7 (ATH 5). It targets an epitope with in 19 amino acids from the bHLH domain.
      IsotypeIgG
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse. Predicted to react with Rat based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ATOH7
      • ATH5
      • BHLHA13
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~17 kDa observed; 16.87 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse retina tissue lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected ATH5 in mouse retina tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications