MABC765 Anti-ALDH3A1, clone EPR7406, Rabbit Monoclonal Antibody

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MABC765
100 µL  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R WB Rb Unpurified Monoclonal Antibody
      Description
      Catalogue NumberMABC765
      DescriptionAnti-ALDH3A1, clone EPR7406, Rabbit Monoclonal Antibody
      Alternate Names
      • Aldehyde dehydrogenase
      • dimeric NADP-preferring
      • ALDHIII
      • Aldehyde dehydrogenase 3
      • Aldehyde dehydrogenase family 3 member A1
      • ALDH3A1
      • ALDH3
      Background InformationAldehyde dehydrogenase or dimeric NADP-preferring or ALDHIII or Aldehyde dehydrogenase 3 or Aldehyde dehydrogenase family 3 member A1, and encoded by the gene name ALDH3A1 or ALDH3, is a member of the aldehyde dehydrogenase (ALDH) superfamily. The ALDH family is a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. ALDHs are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. They are suggested to play a major role in the detoxification of alcohol-derived acetaldehyde. ALDH3A1 is shown to oxidize preferentially aromatic aldehyde substrates, and it may play a role in the oxidation of toxic aldehydes. ALDH3A1 is highly expressed in stomach, esophagus, lung, and cornea. It represents between 5 to 50% of the water soluble protein fraction in mammalian corneas and it is implied to protect the cornea from UV-induced oxidative stress.« Collapse
      References
      Product Information
      FormatUnpurified
      PresentationRabbit monoclonal in buffer containing PBS with up to 0.1% sodium azide, 0.05% BSA, and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-ALDH3A1 antibody is validated for use in Western Blotting for the detection of ALDH3A1.
      Key Applications
      • Western Blotting
      Application NotesProduced in collaboration with Epitomics™
      Biological Information
      ImmunogenSynthetic peptide corresponding to the C-terminus of human ALDH3A1.
      EpitopeC-terminus
      CloneEPR7406
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityEquilibrium disassociation constant (KD) is 9.00 x 10 -10 M
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • ALDH3A1
      • ALDH3
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~50 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A549, mouse eyeball, and rat eyeball lysates.

      Western Blotting Analysis: A 1:1,000-10,000 dilution of this antibody detected ALDH3A1 in A549, mouse eyeball, and rat eyeball lysates.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies