MABC121 Anti-ALDH3A1, clone 10C7.1 Antibody

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MABC121
100 µg  
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      Overview

      Replacement Information

      Key Specifications Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H WB, IHC M Purified Monoclonal Antibody
      Description
      Catalogue NumberMABC121
      DescriptionAnti-ALDH3A1, clone 10C7.1 Antibody
      Alternate Names
      • Aldehyde dehydrogenase, dimeric NADP-preferring
      • ALDHIII
      • Aldehyde dehydrogenase 3
      • Aldehyde dehydrogenase family 3 member A1
      Background InformationAldehyde dehydrogenase family 3 member A1 (ALDH3A1 or Aldh3A1) is a member of the aldehyde dehydrogenase (ALDH) superfamily. The ALDH family is a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. ALDHs are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. They are suggested to play a major role in the detoxification of alcohol-derived acetaldehyde. ALDH3A1 is shown to oxidize preferentially aromatic aldehyde substrates, and it may play a role in the oxidation of toxic aldehydes. ALDH3A1 is highly expressed in stomach, esophagus, lung, and cornea. It represents between 5 to 50% of the water soluble protein fraction in mammalian corneas and it is implied to protect the cornea from UV-induced oxidative stress.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Aldehyde Dehydrogenase using this mouse monoclonal antibody, Anti-ALDH3A1, clone 10C7.1 Antibody validated for use in western blotting & IHC.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ALDH3A1 in human stomach and lung tissues.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of human ALDH3A1.
      EpitopeN-terminus
      Clone10C7.1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ALDH3A1
      • ALDH3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~50 kDa observed. Uncharacterized band(s) may be observed in some cell lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A549 cell lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected ALDH3A1 in 10 µg of A549 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies