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164640 Sigma-AldrichAminopurvalanol A - CAS 220792-57-4 - Calbiochem

A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Brochures
Data Sheet

Synonyms: (2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35

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Overview

Replacement Information

Key Specifications Table

CAS #	Empirical Formula
220792-57-4	C₁₉H₂₆ClN₇O

Pricing & Availability

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Description
Overview	A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI₅₀ = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI₅₀ of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC₅₀ = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC₅₀ ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G₂/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
Catalogue Number	164640
Brand Family	Calbiochem®
Synonyms	(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97

References
References	Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880. Knockaert, M., et al. 2002.Oncogene 21, 6413. Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929. Knockaert, M., et al. 2000. Chem. Biol. 7, 411. Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797. Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.

Product Information
CAS number	220792-57-4
ATP Competitive	Y
Declaration	Sold under license of U.S. Patent 6,255,485 and 6,617,331.
Form	Pale yellow solid
Hill Formula	C₁₉H₂₆ClN₇O
Chemical formula	C₁₉H₂₆ClN₇O
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
Primary Target IC<sub>50</sub>	33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35
Purity	≥98% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Identification Number
Catalog Number	GTIN
164640-5MG	4055977207644

Documentation

Aminopurvalanol A - CAS 220792-57-4 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Certificates of Analysis

Title	Lot Number
164640	Enter Lot Number

References

Reference overview
Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880. Knockaert, M., et al. 2002.Oncogene 21, 6413. Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929. Knockaert, M., et al. 2000. Chem. Biol. 7, 411. Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797. Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.

Brochure

Title
MAPK Pathway Poster ( 750 KB )

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-April-2008 RFH
Synonyms	(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
Description	A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI₅₀ ~1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI₅₀ of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC₅₀ = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~100-fold greater selectivity over a panel of kinases tested (IC₅₀ ≥2.4 µM). Shown to induce cell differentiation by preferentially targeting the G₂/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
Form	Pale yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	220792-57-4
Chemical formula	C₁₉H₂₆ClN₇O
Structure formula
Purity	≥98% by HPLC
Solubility	DMSO (40 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Irritant
References	Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880. Knockaert, M., et al. 2002.Oncogene 21, 6413. Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929. Knockaert, M., et al. 2000. Chem. Biol. 7, 411. Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797. Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.

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