124011 Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₃₁H₂₇IN₄S 681281-88-9

Pricing & Availability

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124011-1MG
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      Glass bottle 1 mg
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      124011-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available.
          Catalogue Number124011
          Brand Family Calbiochem®
          References
          ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



          Selected Citations
          Lee, J., et al. 2009. Cell Stem Cell 5, 76.


          Product Information
          CAS number681281-88-9
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₃₁H₂₇IN₄S
          Chemical formulaC₃₁H₂₇IN₄S
          Hygroscopic Hygroscopic
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationAkt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
          Biological Information
          Primary TargetAkt
          Primary Target IC<sub>50</sub>625 nM in blocking Akt-mediated FOXO1a nuclear export; < 1.25 µM in blocking Akt-mediated cell proliferation in 786-O cells
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Akt Inhibitor IV - CAS 681281-88-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          124011

          References

          Reference overview
          Kau, T.R., et al. 2003. Cancer Cell 4, 463.



          Selected Citations
          Lee, J., et al. 2009. Cell Stem Cell 5, 76.


          Citations

          Title
        • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision23-November-2009 RFH
          DescriptionA cell-permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3-K.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number681281-88-9
          Chemical formulaC₃₁H₂₇IN₄S
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesKau, T.R., et al. 2003. Cancer Cell 4, 463.



          Selected Citations
          Lee, J., et al. 2009. Cell Stem Cell 5, 76.


          Citation
        • Chengyu Wu and Jiaoti Huang. (2007) Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer. Journal of Biological Chemistry 282, 3571-3583.