|Aervent®-50 Capsule Filters|
|Sterile Filtration of Gases by Membrane Filters|
Leahy, Timothy J., and Raymond Gabler
Vol. XXVI: 836-843. 1984
|What is the difference between Aerex and Aervent?||Aervent cartridges have a 0.2µ PTFE membrane and are used in pharmaceutical applications where it is critical to use a phobic filter that has proven bacterial and viral retention capabilities. Common applications for Aervent are fermentation air applications, bioreactor inlet and outlet filtration and sterile process gases. Aervent filters have a liquid bacterial retention claim as well as a virus aerosol retention claim.
Aerex filters also have a 0.2µ PTFE membrane but they do not come with a liquid bacterial retention claim. Common applications for Aerex include bulk intermediate manufacturing and non-pharamaceutical applications such as industrial fermentation. Aerex filters do have a virus aerosol retention claim.
|Can I mount my tank vent filter horizontally?||Millipore recommends that you mount your vent filter vertically because it will facilitate the draining of any condensate that may collects in the bottom of the housing. If condensate builds up in the housing, it can cause part of the filter to becomes wet which will prevent air from passing through.|
Optiseal Cartridge Filters with Hydrophobic Aervent MembraneOptiseal filters with Aervent membrane are designed for sterilizing applications, removing particles and microorganisms from gases and solvents.
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|Biopharmaceutical Manufacturing > Downstream Processing > Sterile Filtration > Sterile Gas > Aervent > Aervent 50|
Aervent-50 0.2 µm hydrophobic filters contain a 50 mm Aervent PTFE membrane in a bi-directionally supported polypropylene casing. This sterilizing-grade filter is designed for critical small scale gas line and air venting applications. The hydrophobic Aervent PTFE membrane provides high flow rates and throughput, low extractables and particle shedding, and broad chemical compatibility.
For traceability and easy identification, each Aervent-50 filter is hot stamped with its catalogue number and lot number. Each Aervent-50 filter is integrity tested during manufacture.
- Sterile venting of vessels and carboys
- Autoclave vacuum break lines
- Low volume sterile filtration of non-aqueous fluids
- Small fermenter inlet and exhaust gas filtration
|Materials of Construction|
|Filter||Hydrophobic Polytetrafluoroethylene (PTFE)|
|Filtration Area||19.6 cm²|
|Maximum Inlet Pressure, bar (psi)||4.1 bar (60 psi) @ 25 °C|
|Bacterial Retention||Quantitative retention of 107 CFU/cm2 Brevundimonas diminuta (ATCC® 19146) per ASTM® F838-83 methodology|
|Bacterial Endotoxins||Aqueous extraction contains ≤0.5 EU/mL as determined by the Limulus Amebocyte Lysate (LAL) Test|
|Gravimetric Extractables||≤1.0 mg in 70/30 % IPA/water|
|Sterilization||10 autoclave cycles of 30 min @ 130 °C; not in-line steam sterilizable|
|Integrity Test - Bubble Point||≥1100 mbar (16 psig) nitrogen with 60/40 % IPA/water|