118500 ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem

118500
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₁₇NO₃S₂ 587871-26-9

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118500-10MG
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      Glass bottle 10 mg
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      118500-2MG
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          Description
          OverviewA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5 , 9.3 , 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 = µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents. A 10 mM (2 mg/506 µl) solution of ATM Kinase Inhibitor (Cat. No. 118502) in DMSO is also available.
          Catalogue Number118500
          Brand Family Calbiochem®
          Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
          References
          ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
          Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
          Hickson, I., et al. 2004. Cancer Res. 64, 9152.
          Product Information
          CAS number587871-26-9
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₂₁H₁₇NO₃S₂
          Chemical formulaC₂₁H₁₇NO₃S₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetATM Kinase
          Primary Target IC<sub>50</sub>13 nM
          Primary Target K<sub>i</sub>2.2 nM for ATM kinase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          ATM Kinase Inhibitor - CAS 587871-26-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          118500

          References

          Reference overview
          Pereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
          Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
          Hickson, I., et al. 2004. Cancer Res. 64, 9152.

          Brochure

          Title
          New Research Tools for Signal Transduction and Life Science Research
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-February-2014 JSW
          Synonyms2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, KU 55933, KU55933, KU-55933
          DescriptionA cell-permeable disubstituted pyranone compound that acts as a potent and ATP-competitive inhibitor of ATM kinase (IC50 = 13 nM; Ki = 2.2 nM). Displays excellent selectivity over other PIKK family kinases (IC50 = 2.5, 9.3, 16.6 µM for DNA-PK, mTOR, PI 3-K, respectively; IC50 > 100 µM for PI 4-K and ATR) and exhibits little activity towards a panel of 60 other kinases even at concentrations as high as 10 µM. Inhibits ATM-dependent cellular protein phosphorylation following ionizing radiation (IR) and sensitizes cells with wild-type ATM, but not mutant ATM, to the cytotoxic effects of IR and DNA-damaging agents.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number587871-26-9
          Chemical formulaC₂₁H₁₇NO₃S₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (4 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesPereg, Y., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 5056.
          Lau, A., et al. 2005. Nat. Cell Biol. 7, 493.
          Hickson, I., et al. 2004. Cancer Res. 64, 9152.