533464 AMPK Activator, COH-SR4 - Calbiochem

533464
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₃H₈Cl₄N₂O

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      Glass bottle 10 mg
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      Description
      OverviewA cell permeable, orally bioavailable bis(dichlorophenyl)urea that acts as an AMPK activator via possibly targeting upstream of AMPK. Shown to increase AMPK phosphorylation and activation in multiple preadipocytes and cancer cell lines dose-dependently. Inhibits glutathione S transferase (GST) activity and induces G2/M phase cell cycle arrest in multiple melanoma cells (IC50 = 5-11 µM). Effectively inhibits tumor burden, decreases angiogenesis marker CD31 and proliferation marker Ki67, and increases pAMPK levels in vivo (4 mg/kg p.o., mouse) without obvious toxicity. Displays similar anti-cancer effects in lung cancer models both in vitro and in vivo. In addition, shown to down-regulate key proteins involved in fatty acid synthesis and inhibits adipocyte differentiation via AMPK activation in 3T3-L1 obesity model cells (IC50 = ~1.5 µM).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number533464
      Brand Family Calbiochem®
      SynonymsSR4
      References
      ReferencesSinghal, S. S., et al. 2013. Biochem. Pharm. 86, 1664.
      Figarola, J. L., et al. 2013. Int. J. Mol. Med. 31, 1166.
      Singhal, S. S., et al. 2012. Biochem. Pharm. 84, 1419.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₃H₈Cl₄N₂O
      Chemical formulaC₁₃H₈Cl₄N₂O
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>5-11 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      AMPK Activator, COH-SR4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Singhal, S. S., et al. 2013. Biochem. Pharm. 86, 1664.
      Figarola, J. L., et al. 2013. Int. J. Mol. Med. 31, 1166.
      Singhal, S. S., et al. 2012. Biochem. Pharm. 84, 1419.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-November-2015 JSW
      SynonymsSR4
      DescriptionA cell permeable, orally bioavailable bis(dichlorophenyl)urea that acts as an AMPK activator via possibly targeting upstream of AMPK. Shown to increase AMPK phosphorylation and activation in multiple preadipocytes and cancer cell lines dose-dependently. Inhibits glutathione S transferase (GST) activity and induces G2/M phase cell cycle arrest in multiple melanoma cells (IC50 = 5-11 µM). Effectively inhibits tumor burden, decreases angiogenesis marker CD31 and proliferation marker Ki67, and increases pAMPK levels in vivo (4 mg/kg p.o., mouse) without obvious toxicity. Displays similar anti-cancer effects in lung cancer models both in vitro and in vivo. In addition, shown to down-regulate key proteins involved in fatty acid synthesis and inhibits adipocyte differentiation via AMPK activation in 3T3-L1 obesity model cells (IC50 = ~1.5 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₃H₈Cl₄N₂O
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSinghal, S. S., et al. 2013. Biochem. Pharm. 86, 1664.
      Figarola, J. L., et al. 2013. Int. J. Mol. Med. 31, 1166.
      Singhal, S. S., et al. 2012. Biochem. Pharm. 84, 1419.