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505315 A 438079 - CAS 899507-36-9 - Calbiochem

505315
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Empirical FormulaCAS #
C₁₃H₉Cl₂N₅•HCl 899507-36-9

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      Description
      OverviewA potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5 nM and 6.9 nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10 µM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300 nM at rat and human P2X7 receptors, respectively.
      Catalogue Number505315
      Brand Family Calbiochem®
      Synonyms3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride, P2X7 Purinergic Receptor Antagonist, A 438079, A438079, A-438079
      References
      ReferencesDonnelly-Roberts, et al., 2007, Br. J. Pharmacol. 101, 571.
      Wang B, et al., 2013, Purinergic Signal. 9, 101.
      Product Information
      CAS number899507-36-9
      FormOff-white solid
      Hill FormulaC₁₃H₉Cl₂N₅•HCl
      Chemical formulaC₁₃H₉Cl₂N₅•HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP2X₇
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      A 438079 - CAS 899507-36-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Donnelly-Roberts, et al., 2007, Br. J. Pharmacol. 101, 571.
      Wang B, et al., 2013, Purinergic Signal. 9, 101.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      Synonyms3-((5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methyl)pyridine hydrochloride, P2X7 Purinergic Receptor Antagonist, A 438079, A438079, A-438079
      DescriptionA potent, competitive, and selective antagonist of P2X7 purinergic receptor (pIC50 = 6.5 nM and 6.9 nM for rat and human P2X7 receptor, respectively). Shown to reduce ATP-induced reactive oxygen species formation in MEL cells by about 87% (~10 µM) and blocks BzATP-stimulated changes in intracellular calcium concentrations (IC50 = 100 and 300 nM at rat and human P2X7 receptors, respectively.
      FormOff-white solid
      CAS number899507-36-9
      Chemical formulaC₁₃H₉Cl₂N₅•HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDonnelly-Roberts, et al., 2007, Br. J. Pharmacol. 101, 571.
      Wang B, et al., 2013, Purinergic Signal. 9, 101.