Key Specifications Table
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|499610-1MG||Glass bottle||1 mg||
|Overview||A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.|
|CAS number||66018-38-0, 253863-19-3|
|Structure formula Image|
|Purity||≥97% by HPLC|
|Safety Information according to GHS|
|S Phrase||S: 22-24/25-36/37/39
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
|Product Usage Statements|
(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem SDS
|Windheim, M., et al. 2007. Biochem. J. 404, 179.
Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
Safwat, N., et al. 2005. Endocrinology 146, 4814.
Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
|Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.