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505413 5-Iodo-A-85380 dihydrochloride hydrate - CAS 213550-82-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380

Primary Target: α4β2 nAChR
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      213550-82-4C₉H₁₁IN₂O•2HCl•xH2O
      Description
      OverviewA very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (Ki= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.
      Catalogue Number505413
      Brand Family Calbiochem®
      Synonyms3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380
      References
      ReferencesLiu, X., et al., 2013. Psychopharm. In press.
      Kennett, A., et al., 2012. Nicotine Tob. Res. 14, 1339.
      Huang. LZ, et al., 2011. Neuropharm. 60, 861.
      Mogg. AJ, et al., 2004. Neuropharm. 60, 861.
      Mukhin, A.G., et al., 2000. Mol. Pharmacol. 47, 848.
      Product Information
      CAS number 213550-82-4
      FormOff-white powder
      Hill FormulaC₉H₁₁IN₂O•2HCl•xH2O
      Chemical formulaC₉H₁₁IN₂O•2HCl•xH2O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetα4β2 nAChR
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      505413

      Documentation

      5-Iodo-A-85380 dihydrochloride hydrate - CAS 213550-82-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Liu, X., et al., 2013. Psychopharm. In press.
      Kennett, A., et al., 2012. Nicotine Tob. Res. 14, 1339.
      Huang. LZ, et al., 2011. Neuropharm. 60, 861.
      Mogg. AJ, et al., 2004. Neuropharm. 60, 861.
      Mukhin, A.G., et al., 2000. Mol. Pharmacol. 47, 848.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms3-((2S)-2-Azetidinylmethoxy)-5-iodo-pyridine dihydrochloride hydrate, α4β2 and α6β2 Nicotinic Acetylcholine Receptors (nAChR) Agonist, 5-Iodo-A-85380
      DescriptionA very potent agonist highly selective for α4β2 and α6β2 nicotinic acetylcholine receptors (nAChR) (Ki= 12 and 10 pM for human and rat α4β2 nAChRs, respectively). An important nAChR ligand for the treatment of pain, smoking addition and other mental disorders.
      FormOff-white powder
      CAS number 213550-82-4
      Chemical formulaC₉H₁₁IN₂O•2HCl•xH2O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (22 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLiu, X., et al., 2013. Psychopharm. In press.
      Kennett, A., et al., 2012. Nicotine Tob. Res. 14, 1339.
      Huang. LZ, et al., 2011. Neuropharm. 60, 861.
      Mogg. AJ, et al., 2004. Neuropharm. 60, 861.
      Mukhin, A.G., et al., 2000. Mol. Pharmacol. 47, 848.