565765 γ₄₀-Secretase Inhibitor I - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₃H₃₄N₂O₅

Pricing & Availability

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565765-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA potent, cell-permeable, reversible γ-secretase inhibitor that preferentially appears to inhibit the secretion of Aβ1-40 (>90%) over Aβ1-42 (~15%). Aβtotal IC50 ~ 15 µM; Aβ1-40 IC50 ~ 22 µM; Aβ1-42 IC50 > 50 µM in CHO cells stable transfected with the cDNA encoding βAPP695. Reported to be about 10-fold more potent than Z-Val-Phe-CHO (MDL 28170; Cat. No. 208722).
      Catalogue Number565765
      Brand Family Calbiochem®
      Synonymst-3,5-DMC-IL-CHO, N-trans-3,5-Dimethoxycinnamoyl)-Ile-leucinal
      References
      ReferencesHigaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₃H₃₄N₂O₅
      Chemical formulaC₂₃H₃₄N₂O₅
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetsecretion of Aβ₁₋₄₀
      Primary Target IC<sub>50</sub>~ 15 µM for Aβtotal; ~ 22 µM for Aβ1-40; < 50 µM for Aβ1-42 in CHO cells stable transfected with the cDNA encoding βAPP695
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide Sequencetrans-3,5-DMC-Ile-Leu-CHO (DMC = Dimethoxycinnamoyl)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      γ₄₀-Secretase Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      γ₄₀-Secretase Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      565765

      References

      Reference overview
      Higaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      Synonymst-3,5-DMC-IL-CHO, N-trans-3,5-Dimethoxycinnamoyl)-Ile-leucinal
      DescriptionA potent, cell-permeable, reversible inhibitor of γ-secretase that is reported to preferentially inhibit the secretion of Aβ1-40 (>90%) vs. Aβ1-42. IC50 = ~15 µM for Aβtotal; ~22 µM for Aβ1-40; and >50 µM for Aβ1-42 in CHO cells stably transfected with the cDNA encoding βAPP695. Reported to be about 10-fold more potent than Z-Val-Phe-CHO [MDL 28170 (Cat. No. 208722)].
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₃H₃₄N₂O₅
      Peptide Sequencetrans-3,5-DMC-Ile-Leu-CHO (DMC = Dimethoxycinnamoyl)
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesHigaki, J.N., et al. 1999. J. Med. Chem. 42, 3889.