164603 Sigma-Aldrich3-Nitropropionic acid - CAS 504-88-1 - Calbiochem

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: 3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA

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Overview

Replacement Information

Key Specifications Table

CAS #	Empirical Formula
504-88-1	C₃H₅NO₄

Pricing & Availability

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Description
Overview	A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
Catalogue Number	164603
Brand Family	Calbiochem®
Synonyms	3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA

References
References	Beal, M., et al. 1993, J. Neurosci. 13, 4181. Pang, Z., et al. 1997, J. Neuroscience 17, 3064. Huang, L., et al. 2006, J. Bio. Chem. 281, 5965. Garcia, M., et al. 2002, J. Neurosci. 22, 2174. Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.

Product Information
CAS number	504-88-1
Form	Light yellow powder
Hill Formula	C₃H₅NO₄
Chemical formula	C₃H₅NO₄
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥98% by NMR

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information
R Phrase	R: 25-36/37/38 Toxic if swallowed. Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Toxic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Documentation

3-Nitropropionic acid - CAS 504-88-1 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

3-Nitropropionic acid - CAS 504-88-1 - Calbiochem Certificates of Analysis

Title	Lot Number
164603	Enter Lot Number

References

Reference overview
Beal, M., et al. 1993, J. Neurosci. 13, 4181. Pang, Z., et al. 1997, J. Neuroscience 17, 3064. Huang, L., et al. 2006, J. Bio. Chem. 281, 5965. Garcia, M., et al. 2002, J. Neurosci. 22, 2174. Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	15-June-2012 JSW
Synonyms	3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
Description	A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
Form	Light yellow powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	504-88-1
Chemical formula	C₃H₅NO₄
Structure formula
Purity	≥98% by NMR
Solubility	DMSO or Ethanol (100 mg/ml)
Storage	Protect from light +2°C to +8°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Toxic
References	Beal, M., et al. 1993, J. Neurosci. 13, 4181. Pang, Z., et al. 1997, J. Neuroscience 17, 3064. Huang, L., et al. 2006, J. Bio. Chem. 281, 5965. Garcia, M., et al. 2002, J. Neurosci. 22, 2174. Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.