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251010 1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
147-94-4C₉H₁₃N₃O₅

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251010-1GM
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      Description
      OverviewAnticancer, antiviral agent that is especially effective against leukemias. Induces apoptosis in human myeloid leukemia cells and in rat sympathetic neurons. Induces G1/S phase cell cycle arrest.
      Catalogue Number251010
      Brand Family Calbiochem®
      SynonymsAra-C, Cytarabine, Cytosine Arabinoside
      References
      ReferencesZarilli, R., et al. 1999. Gastroenterology 116, 1358.
      Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
      Grant, S., et al. 1994. Oncol. Res. 6, 87.
      Greenberg, A.L., et al. 1994. Cancer 74, 1261.
      Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
      Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
      Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
      Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
      Este, E., et al. 1992. Blood 79, 2246.
      Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
      Product Information
      CAS number147-94-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₉H₁₃N₃O₅
      Chemical formulaC₉H₁₃N₃O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAnticancer, antiviral agent that is especially effective against leukemias
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSHA5425000
      Safety Information
      R PhraseR: 20/21/22-36/37/38-43-61

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      May cause harm to the unborn child.
      S PhraseS: 22-36-45

      Do not breathe dust.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      1-β-D-Arabinofuranosylcytosine - CAS 147-94-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      251010

      References

      Reference overview
      Zarilli, R., et al. 1999. Gastroenterology 116, 1358.
      Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
      Grant, S., et al. 1994. Oncol. Res. 6, 87.
      Greenberg, A.L., et al. 1994. Cancer 74, 1261.
      Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
      Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
      Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
      Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
      Este, E., et al. 1992. Blood 79, 2246.
      Owens, J.K., et al. 1992. Cancer Res. 52, 2389.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2019 JSW
      SynonymsAra-C, Cytarabine, Cytosine Arabinoside
      DescriptionCytosine analog that acts as a potent inhibitor of eukaryotic cellular and viral replicative DNA synthesis. AraCTP, formed by intracellular phosphorylation of AraC, is utilized as a substrate by DNA polymerases, which incorporate AraCMP residues into DNA. Incorporated 3'-terminal AraCMP residues inhibit further DNA synthesis by impeding chain elongation by DNA polymerase. AraC is used clinically in the treatment of various cancers, particularly leukemias and lymphomas. Also used to inhibit proliferation of cultured cells and replication of eukaryotic viruses (e.g. vaccinia virus, herpes simplex virus). Also shown to induce apoptosis in human myeloid leukemia cells and in post-mitotic rat sympathetic neurons.
      FormWhite solid
      CAS number147-94-4
      RTECSHA5425000
      Chemical formulaC₉H₁₃N₃O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (1 mM)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 2784
      ReferencesZarilli, R., et al. 1999. Gastroenterology 116, 1358.
      Dessi, F., et al. 1995. J. Neurochem. 64, 1980.
      Grant, S., et al. 1994. Oncol. Res. 6, 87.
      Greenberg, A.L., et al. 1994. Cancer 74, 1261.
      Perrino, F.W., et al. 1997. J. Biol. Chem. 269, 16357.
      Tomkins, C.E., et al. 1994. J. Cell Sci. 107, 1499.
      Taddie, J.A., and Traktman, P. 1993. J. Virol. 67, 4323.
      Brach, M.A., et al. 1992. Mol. Pharmacol. 41, 60.
      Este, E., et al. 1992. Blood 79, 2246.
      Owens, J.K., et al. 1992. Cancer Res. 52, 2389.