Product Information
Applications
Biological Information
Primary Targetmonomeric α-synuclein
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

α-Synuclein Blocker, ELN484228 - CAS 312-63-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Toth, G., et al. 2014. PLoS ONE 9, e87133.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-May-2014 JSW
SynonymsN-(4-Fluorophenyl)benzenesulfonamide, NSC164389, ELN 484228
DescriptionA cell-permeable phenylsulfonamide compound that reversibly binds to pocket I of the monomeric α-synuclein (α-syn) and reverses α-syn-induced impairment of phagocytosis in H4 neuroglioma cells over-expressing wild-type α-syn and microglia isolated from α-syn BAC transgenic animals over-expressing the E46K mutant form of human α-syn (~1-10 µM). Reduces α-syn-mediated impairment of vesicular dynamics and diminishes α-syn translocation to the synaptic region in rat primary neuronal cultures by 50% (at ~ 1 µM) and in cortical cultures in transgenic mice over-expressing human α-syn. Also shown to protect dopaminergic neurons against the toxic effects of over-expressed α-syn A53T and reduces neurite retraction in TH- and MAP2-positive neurons.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number312-63-0
Chemical formulaC₁₂H₁₀FNO₂S
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesToth, G., et al. 2014. PLoS ONE 9, e87133.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurobiology / Neurodegeneration