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Cancer Biomarker Assays Using Luminex® Technology

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Induction of receptor tyrosine kinase signaling by sera isolated from patients with lung adenocarcinoma

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Dr. Jeffery A. Borgia, Professor of Pathology and Biochemistry in the Thoracic-Oncology Research Group, Rush University Medical Center
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Read the SelectScience Article about Dr. Jeffery A. Borgia’s research: "Discover How Researchers at Rush Medical Center are Developing Novel Diagnostic Tests for Non-Small Cell Lung Cancer"

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For cancer biomarker detection, count on flexible, consistent MILLIPLEX® multiplex assay panels using trusted Luminex xMAP® technology.

Biomarker Detection in Cancer Research

A tumor marker, or “biomarker,” is a molecular entity whose relative quantity or localization is different between tumor-bearing and non-tumor-bearing subjects. Cancer biomarker detection is important — not only for therapeutic use, but also because they can be used to decipher the signaling pathways underlying both normal and diseased cellular processes.

Accelerate Your Cancer Research using MILLIPLEX® Multiplex Assays

Detection of isolated protein biomarkers is often inadequate to distinguish tumor from non-tumor. Multiplexed detection of both intracellular and circulating cancer markers can accelerate studies of normal homeostasis and tumorigenic processes, as long as your assays exhibit accuracy and lot-to-lot consistency.

Using the bead-based Luminex xMAP® platform, our MILLIPLEX® cancer portfolio provides a broad offering of multiplexed cancer marker assays, compatible with serum, plasma, tissues, cultured cells, and other biological samples.

Our analytically verified kits and assays enable you to measure specific proteins in cancer research areas.

Some examples of the multiplex assay analytes in our portfolio are listed below. Download the Analyte Quarterly brochure for a complete, updated list of assays.

Checkpoint Protein Markers*:

BTLA CTLA-4 HVEM
CD27 FGL1 ICOS
CD28 Gal-1 LAG-3
CD40 Gal-3 PD-1
CD80/B7-1 GITR PD-L1
CD86/B7-2 GITRL PD-L2
*Selected analytes shown

Circulating Tumor Markers*:

BTLA CD86/B7-2 ICOS
CD27 CTLA-4 LAG-3
CD28 GITR PD-1
CD40 GITRL PD-L1
CD80/B7-1 HVEM TIM-3
*Selected analytes shown

Circulating Tumor Markers*:

AFP CA-125 Leptin
CEA MIF VEGF-A-A
TRAIL PSA Osteopontin
Antithrombin III Vitamin D binding protein Ferritin
Galectin 3 Myeloperoxidase (MPO) IGFBP3
*Selected analytes shown

Angiogenesis*:

Angiopoietin-2 Follistatin BMP9
EGF Endoglin HGF
sHER2 sNeuropilin-1 VEGF-C
VEGF-D Endothelin-1 Thrombospondin-2
*Selected analytes shown

Metastasis*:

NSE Periostin TWEAK
YKL40 TRAP DKK1
OPG Osteonectin GDF15
MMP-9 HGF MMP-2
*Selected analytes shown

To expand the power of your cancer research, we also offer Luminex® multiplex assays for:

Luminex Technology

New to Multiplexing?

Click here to learn more about how Luminex technology works.

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MILLIPLEX® Analyte Kit Finder

Use the kit finder below to choose the correct assays for your biomarkers of interest, so you can obtain the best quality data the first time.
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