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Filtration Methods for Dissolution Testing

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Syringe filters remove undissolved active ingredients to get samples from exact time points.
Syringe filtration of dissolution testing samples removes undissolved active compounds, stopping the dissolution process and ensuring that each sample accurately represents the collection time point.
Spectroscopic analyses of pharmaceutical compounds in conjunction with dissolution testing plays a critical role in drug characterization and tablet quality control. Syringe filtering samples before spectroscopic analysis removes undissolved active compounds, stopping the dissolution process and ensuring that each sample provides an accurate representation of the collection time point. Undissolved particulates in dissolution samples, if not removed by the appropriate filter, continue to dissolve downstream, reaching downstream instrumentation such as HPLC. These particles are a major cause of variable test results and clogged HPLC columns that increase backpressure and shorten column lifetime.

Multiple syringe filters

Filtration Solutions for Dissolution Testing

Millex® syringe filters meet sample preparation demands for dissolution and other pharmaceutical QC analyses. For buffer and solvent preparation, our vacuum filtration products include membrane discs, filter holders and accessories for large volume filtration requirements.

Millex® Syringe Filters Ensure Reproducible Results and Maximize Uptime of Dissolution Testing Equipment.

The low drug-binding and low extractable characteristics exhibited by all Millex® syringe filters ensure high-quality, reproducible dissolution results that can improve the efficiency, throughput and longevity of expensive analytical equipment.

High Analyte Recovery from Millex® Syringe Filters

High analyte recovery with our Millex® syringe filters.

Low Extractables from Millex® Syringe Filters

Low extractables with our Millex® syringe filters

Filter Your Dissolution Testing Samples Using:

Filter Your Dissolution Mobile Phases Using: