Hard-to-Filter Samples in Dissolution Testing |
Request Information |
HPF Millex® Filters for High Particulate Filtration |
|---|
 Sample volume: >10mL Features: Integrated prefilter yielding 2-4X greater throughput than traditional syringe filters.Learn More |
Hard-to-Filter Samples in Dissolution Testing
Often times dissolution testing samples are viscous and/or contain high levels of particulates. Viscous samples can greatly slow down filtration rate, and high levels of particulates may clog the filter membrane’s pores. For these dissolution testing samples, we recommend using filtration devices optimized for hard-to-filter samples.High Particle Filtration
25 mm HPF Millex® syringe filters are the right choice for high particulate load samples. HPF Millex® syringe filters include a graduated glass fiber prefilter to remove larger particles and either a 0.20 μm or 0.45 μm membrane filter for fine filtration. This combination of prefilter and membrane provides significantly greater throughput than standard filters without prefiltration media, especially when filtering particle-laden solutions. HPF Millex® syringe filters are available in bulk for individual sample filtration and in tubes for use with automated filter changing systems.
Samplicity® Filtration System |
|---|
 Sample volume: 300 µL – 2 mL Features: Prepares multiple samples simultaneously; ergonomic design; vacuum-driven device improves throughput and sample recovery. Learn More |
Samplicity® Filtration System for Hard-to-Filter Samples
If manual filtration for hard-to-filter dissolution testing samples, these samples can require excessive manual force, greater time per sample, and lower recovery — all reducing laboratory efficiency. In contrast, the Samplicity® filtration system filters even highly viscous samples in seconds, with minimal manual force.
Sample |
Concentration Filtered, % |
Viscosity, Centipoises |
Filtration time, seconds |
% RSD |
|---|---|---|---|---|
Pepto Bismol |
2 | 2.3 | 17.3 | 2 |
Calamine diphenylhydramin lotion |
5 | 510.0 | 32.8 | 2 |
Milk of magnesia |
100 | 10088.0 | 35.5 | 1 |
DayQuil cold and flu syrup |
10 | 3.6 | 53.5 | 1 |
Millex Samplicity® filters with 0.45 µm PVDF membrane were used to efficiently clarify hard-to-filter pharmaceutical samples.
1.0 mL samples of 1% Pepto-Bismol were filtered by 15 users, either through hydrophilic polytetrafluoroethylene (PTFE) Millex® syringe filters with a 10 mL syringe, or through 0.45 µm hydrophilic PTFE Millex Samplicity® membrane filters using the Samplicity® filtration system.
Pre-launch Device Disclaimer: The information presented is based on preliminary development results. Device performance in specific applications may be different.