SeQuant® Scientific Papers

SeQuant® ZIC®-HILIC HPLC columns solve research problems

Scientists in laboratories around the world have published articles after solving difficult analysis problems using SeQuant® ZIC®-HILIC technology. Perhaps their experience can help to further your own research by providing examples of specific separation conditions for a particular compound type.

Although we do our best to regularly update this application collection, we would appreciate your help.

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1. Water Uptake on Polar Stationary Phases under Conditions for Hydrophilic Interaction Chromatography and Its Relation to Solute Retention
N.P. Dinh, T. Jonsson, K. Irgum
J. Chromatogr. A, xxx (2013) xxx, in press
2. Column comparison and method development for the analysis of short-chain carboxylic acids by zwitterionic hydrophilic interaction liquid chromatography with UV detection
G. Marrubini, A. Pedrali, P. Hemström, T. Jonsson, P. Appelblad, G. Massolini
J. Sep. Sci., 36 (2013) xxx, in press
3. Tandem LC columns for the simultaneous retention of polar and nonpolar molecules in comprehensive metabolomics analysis
K.R. Chalcraft, B.E. McCarry
J. Sep. Sci., 36 (2013) xxx, in press
4. Hydrophilic interaction chromatography (HILIC) in the analysis of antibiotics [Review]
G. Kahsay, H. Song, A. Van Schepdael, D. Cabooter, E. Adams
J. Pharma. Biomed. Anal., xxx (2013) xxx, in press
5. Method validation and analysis of nine dithiocarbamates in fruits and vegetables by LC-MS/MS
B. Schmidt, H.B. Christensen, A. Petersen, J.J. Sloth, M.E. Poulsen
Food Additives & Contaminants A, 30 (2013) 1287-1298
6. Serial coupling of RP and zwitterionic hydrophilic interaction LC-MS: Suspects screening of diclofenac transformation products by oxidation with a boron-doped diamond electrode
M. Rajab, G. Greco, C. Heim, B. Helmreich, T. Letzel
J. Sep. Sci., 36 (2013) 3011-3018
7. The retention behaviour of amino acids in hydrophilic interaction liquid chromatography on zwitterionic stationary phases
Z.Y. Wu, J. Liu, H. Shi, P.J. Marriott
J. Sep. Sci., 36 (2013) 2217-2222
8. Serial coupling of reversed-phase and zwitterionic hydrophilic interaction LC/MS for the analysis of polar and nonpolar phenols in wine
G. Greco, S. Grosse, T. Letzel
J. Sep. Sci., 36 (2013) 1379-1388
9. Zwitterionic hydrophilic interaction chromatography coupled withpost-column derivatization for the analysis of glutathione in winesamples
C.K. Zacharis, P.D. Tzanavaras, T.D. Karakosta, D.G. Themelis
Analytica Chimica Acta, 795 (2013) 75-81
10. Role of organic cation transporters in the ocular disposition of its intravenously injected substrate in rabbits: Implications for ocular drug therapy
J. Nirmal, A. Sirohiwal, S. Baskar Singh, N.R. Biswas, V. Thavaraj, R.V. Azad, T. Velpandian
Experimental Eye Research, 116 (2013) 27-35
11. A rapid determination method for ethylenethiourea in potato and cucumber by modified QuEChERS - High performance liquid chromatography-tandem mass spectrometry
L. Zhou, X. Liu, S. Kang, F. Zhang, C. Pan
Food Chemistry, 138 (2013) 1355-1359
12. Determination of methylphenidate in plasma and saliva by liquid chromatography/tandem mass spectrometry
A. Secilir, L. Schrier, Y.A. Bijleveld, J.H. Toersche, S. Jorjani, J. Burggraaf, J. van Gerven, R.A.A. Mathôt
J. Chromatogr. B, 923-924 (2013) 22-28
13. Tracing and separating plasma components causing matrix effects in hydrophilic interaction chromatography-electrospray ionization mass spectrometry
A. Ekdahl, M.C. Johansson, M. Ahnoff
J. Chromatogr. B, 923-924 (2013) 83-91
14. Characterization of a-mannosidase from Dolichos lablab seeds: Partial amino acid sequencing and N-glycan analysis
B.S. Gnanesh Kumar, G. Pohlentz, M. Mormann, N. Siva Kumar
Protein Expression and Purification, 89 (2013) 7-15
15. Morphology, toxicity, and phylogeny of Alexandrium (Dinophyceae) species along the coast of China
H. Gu, N. Zeng, T. Liu, W. Yang, A. Muller, B. Krock
Harmful Algae, 27 (2013) 68-81
16. Prediction of concentration levels of metformin and other high consumption pharmaceuticals in wastewater and regional surface water based on sales data
M. Oosterhuis, F. Sacher, T.L. ter Laak
Science of the Total Environment, 442 (2013) 380-388
17. Analysis of magnesium from magnesium stearate in pharmaceutical tablet formulations using hydrophilic interaction liquid chromatography with nano quantity analyte detection
D.S. Risley, L.E. Magnusson, P.R. Morow, A. Aburub
J. Pharm. Biomed. Anal., 78-79 (2013) 112-117
18. Validation of the analytical procedure for the determination of the neurotoxin B-N-methylamino-l-alanine in complex environmental samples
A. Combes, S. El Abdellaoui, C. Sarazin, J. Vial, A. Mejean, O. Ploux, V. Pichon
Analytica Chimica Acta, 771 (2013) 42-49
19. On-line solid phase extraction-liquid chromatography-mass spectrometry for trace determination of nerve agent degradation products in water samples
B.T. Røena, S.R. Sellevåg, E. Lundanes
Analytica Chimica Acta, 761 (2013) 109-116
20. Characterization of Therapeutic Antibodies and Related Products
A. Beck, E. Wagner-Rousset, D. Ayoub, A. Van Dorsselaer, S. Sanglier-Cianférani
Anal. Chem., 85 (2013) 715-736
21. Glycopeptide Identification Using Liquid-Chromatography-Compatible Hot Electron Capture Dissociation in a Radio-Frequency-Quadrupole Ion Trap
N. Manri, H. Satake, A. Kaneko, A. Hirabayashi, T. Baba,
T. Sakamoto
Anal. Chem., 85 (2013) 2056-2063
22. Effects of the operation parameters on HILIC separation of flavonoids on zwitterionic column
A. Sentkowska, M. Biesaga, K. Pyrzynska
Talanta, 115 (2013) 284-290
23. Practical investigation of the factors that affect the selectivity in hydrophilic interaction chromatography
A. Kumar, J.C. Heaton, D.V. McCalley
J. Chromatogr. A, 1276 (2013) 33-46

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1. A Comparative Study on Three Analytical Methods for the Determination of the Neurotoxin BMAA in Cyanobacteria
E.J. Faassen, F. Gillissen, M. Lurling
PLoS ONE, 7 (2012) e36667
2. Zwitterionic silica-based monolithic capillary columns for isocratic and gradient hydrophilic interaction liquid chromatography
D. Moravcová, J. Planeta, V. Kahle, M. Roth
J. Chromatogr. A, 1270 (2012) 178-185

3. Determination of nicotine exposure in dogs subjected to passive smoking using methanol extraction of hair followed by hydrophilic interaction chromatography
in combination with Fourier transform mass spectrometry
S. Bawazeer, D.G. Watson, C. Knottenbelt
Talanta 88 (2012) 408- 411
4. Optimization of comprehensive two-dimensional gradient chromatography coupling in-line hydrophilic interaction and reversed phase liquid chromatography
P. Jandera, T. Hájek, M. Stanková, K. Vynuchalová, P. Cesla
J. Chromatogr. A 1268 (2012) 91- 101
5. Molecular phylogeny and toxin profiles of Alexandrium tamarense (Lebour) Balech (Dinophyceae) from the west coast of Greenland
C. Baggesen, Ø. Moestrup, N. Daugbjerg, B. Krock, A.D. Cembella, S. Madsen
Harmful Algae 19 (2012) 108-116
6. Determination of glycine in biofluid by hydrophilic interaction chromatography coupled with tandem mass spectrometry and its application to the quantification of glycine released by embryonal carcinoma stem cells
Y.B Tang, L. Teng, F. Sun, X.L. Wang, L. Peng, Y.Y. Cui, J.J. Hu, X. Luan, L. Zhu, H.Z. Chen
J. Chromatogr. B 905 (2012) 61- 66
7. Effects of infusion conditions and decaffeination on free amino acid profiles of green and black tea
T. Kocadağlı, K.S. Özdemir, V. Gökmen
Food Research International xxx (2012) xxx-xxx
8. A hydrophilic interaction liquid chromatography electrospray tandem mass spectrometry method for the simultaneous determination of g-hydroxybutyrate and its precursors in forensic whole blood
L.K. Sørensen, J.B. Hasselstrøm
Forensic Science International 222 (2012) 352-359
9. Non-targeted analysis of tea by hydrophilic interaction liquid chromatography and high resolution mass spectrometry
K. Fraser, S.J. Harrison, G.A. Lane, D.E. Otter, Y. Hemar, S.Y. Quek, S. Rasmussen
Food Chemistry 134 (2012) 1616-1623
10. Depletion of melamine and cyanuric acid in serum from catfish Ictalurus punctatus and rainbow trout Onchorhynchus mykiss
C.B. Stine, C.B. Nochetto, E.R. Evans, C.M. Gieseker, T. D. Mayer, N.R. Hasbrouck, R. Reimschuessel
Food and Chemical Toxicology 50 (2012) 3426-3432
11. Modern approach for determination of lactulose, mannitol and sucrose in human urine using HPLC-MS/MS for the studies of intestinal and upper digestive tract permeability
P. Kubica, A. Kot-Wasik, A. Wasik, J. Namiesnik, P. Landowski
J. Chromatogr. B 907 (2012) 34- 40
12. PSP toxin release from the cyanobacterium Raphidiopsis brookii D9(Nostocales) can be induced by sodium and potassium ions
K. Soto-Liebe, M.A. Méndez, L. Fuenzalida, B. Krock, A. Cembella, M. Vásquez
Toxicon 60 (2012) 1324-1334
13. Experimental design applied to the optimization of microwave-assisted DNA hydrolysis
G. Marrubini, P. Fattorini, C. Previderéc, S. Goi, S.S. Cigliero, P. Grignani, M. Serra, R. Biesuz, G. Massolini
J. Chromatogr. A 1249 (2012) 8- 16
14. Repeated exposure to codeine alters morphineglucuronidation by affecting UGT gene expression in the rat
L. Antonilli, L. DeCarolis, V. Brusadin, A. R. Togna, M. Dovizio, G. I. Togna, P. Patrignani, P. Nencini
European Journal of Pharmacology 693(2012)7-14
15. Benzoic acid and specific 2-oxo acids activate hepatic efflux of glutamate at OAT2
T. Pfennig, B. Herrmann, T. Bauer, E. Schömig, D. Gründemann
Biochimica et Biophysica Acta 1828 (2013) 491-498
16. A mass spectrometric method for quantifying C3 and C6 phosphorylation of starch
M. Carpenter, N. Joyce, R. Butler, R. Genet, G. Timmerman-Vaughan
Analytical Biochemistry 431 (2012) 115-119

17. Stable Isotope-Assisted Metabolomics for Network-Wide Metabolic Pathway Elucidation
D.J. Creek, A. Chokkathukalam, A. Jankevics, K.E.V. Burgess, R. Breitling, M.P. Barrett
Anal. Chem. 84, (2012) 8442-8447
18. A HILIC-MS/MS method for the simultaneous determination of seven organic acids in rat urine as biomarkers of exposure to realgar
Y. Huang, Y Tian, Z. Zhanga, C. Peng
J. Chromatogr. B, 905 (2012) 37-42

19. Study of the retention behavior in zwitterionic hydrophilic interaction chromatography of isomeric hydroxy- and aminobenzoic acids
G. Greco, S. Grosse, T. Letzel
J. Chromatogr. A, 1235 (2012) 60-67
20. Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts
S. Kumar, F.M. Hahn, E. Baidoo, T.S. Kahlon, D.F. Wood, C.M. McMahan, K. Cornish, J.D. Keasling, H. Daniell, M.C. Whalen
Metabolic Engineering. 14,(2012), 19-28
21. A liquid chromatography-tandem mass spectrometry method for the detection of economically motivated adulteration in protein-containing foods
S. MacMahon, T.H. Begley, G.W. Diachenko, S.A. Stromgren
J. Chromatogr. A 1220, (2012), 101-107
22. Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes
H. Hoshi, K. Shimawaki, Y. Takegawa, T. Ohyanagi, M.Amano, H. Hinou, S.I. Nishimura
Biochimica et Biophysica Acta 1820 (2012) 1391-1398
23. Physico-chemical characterisation of cationic DOTAP liposomes as drug delivery system for a hydrophilic decapeptide before and after freeze-drying
A. Wieber, T. Selzer, J. Kreuter
European Journal of Pharmaceutics and Biopharmaceutics, 80, (2012), 358-367
24. Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity
C. Rakers, A.A. Zoerner, S. Engeli, S. Batkai, J. Jordan, D. Tsikas
Analytical Biochemistry 421, (2012), 699-705
25. Development of a hydrophilic interaction liquid chromatography-mass spectrometry method for detection and quantification of urea thermal decomposition by-products in emission from diesel engine employing selective catalytic reduction technology
M.M. Yassine, E. Dabek-Zlotorzynska, V. Celo
J. Chromatogr. A 1229, (2012), 208-215
26. Analysis of volatile bases by high performance liquid chromatography with aerosol-based detection
R.D. Cohen, Y. Liu, X. Gong
J. Chromatogr. A 1229, (2012), 172-179
27. First report of (homo)anatoxin-a and dog neurotoxicosis after ingestion of benthic cyanobacteria in The Netherlands
E.J. Faassen, L. Harkema, L. Begeman, M. Lurling
Toxicon, 60, (2012) 378-384
28. Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria
H. Yamada, N. Akahoshi, S. Kamata, Y. Hagiya, T. Hishiki, Y. Nagahata, T. Matsuura, N. Takano, M. Mori, Y. Ishizaki, T. Izumi, Y. Kumagai, T. Kasahara, M. Suematsu, I. Ishii
Free Radical Biology and Medicine, 52, (2012), 1716-1726
29. Dose-response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats
G. Gamboa da Costa, C.C. Jacob, L.S. Von Tungeln, N.R. Hasbrouck, G.R. Olson, D.G. Hattan, R. Reimschuessel, F.A. Beland
Toxicology and Applied Pharmacology, 262, (2012)  99-106
30. Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones
P. Heffeter, C. Pirker, C.R. Kowol, G. Herrman, R. Dornetshuber, W. Miklos, U. Jungwirth, G. Koellensperger, B.K. Keppler, W. Berger
Biochemical Pharmacology, 83, (2012), 1623-1633
31. Investigations on the stereoselectivity of the phase II metabolism of the 3,4-methylenedioxyethylamphetamine (MDEA) metabolites 3,4-dihydroxyethylamphetamine (DHEA) and 4-hydroxy-3-methoxyethylamphetamine (HMEA)
A.E. Schwaninger, M.R. Meyer, J. Zapp, H.H. Maurer
Toxicology Letters, 212, (2012), 38-47
32. Non-targeted analysis of tea by hydrophilic interaction liquid chromatography and high resolution mass spectrometry
K. Fraser, S.J. Harrison, G.A. Lane, D.E. Otter, Y. Hemar, S.Y. Quek, S. Rasmussen
Food Chemistry, 134, (2012), 1616-1623

33. Evaluation of Coupling Reversed Phase, Aqueous Normal Phase, and Hydrophilic Interaction Liquid Chromatography with Orbitrap Mass Spectrometry for Metabolomic Studies of Human Urine
T. Zhang, D.J. Creek, M.P. Barrett, G. Blackburn, D.G. Watson
Anal. Chem., 84 (2012) 1994-2001
34. Determination of aminoglycoside residues in kidney and honey samples by hydrophilic interaction chromatography-tandem mass spectrometry
P. Kumar, A. Rubies, R. Companyo, F. Centrich
J. Sep. Sci., 35 (2012) 2710-2717

35. Hydrophilic interaction chromatography
for the analysis of aminoglycosides
P. Kumar, A. Rubies, R. Companyo, F. Centrich
J. Sep. Sci., 35 (2012) 498-504

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1. Simultaneous Analysis of Heparan Sulfate, Chondroitin/Dermatan Sulfates, and Hyaluronan Disaccharides by Glycoblotting-Assisted Sample Preparation Followed by Single-Step Zwitter-Ionic-Hydrophilic Interaction Chromatography
Y. Takegawa, K.Araki, N. Fujitani, J. Furukawa, H. Sugiyama, H. Sakai, Y. Shinohara
Anal. Chem. 83, (2011), 9443–9449

2. Hydrophilic Interaction Liquid Chromatography: ESI-MS/MS
of Plasmalogen Phospholipids from Pectinatus Bacterium
T. Rezanka, L. Siristova, D. Matoulkova, K. Sigler
Lipids 46, (2011), 765-780
3. Rapid and simultaneous determination of hexapeptides (Ac-EEMQRR-amide and H2N-EEMQRR-amide) in anti-wrinkle cosmetics by hydrophilic interaction liquid chromatography-solid phase extraction preparation and hydrophilic interaction liquid chromatography with tandem mass spectrometry
W. Zhou, P.G. Wang, A.J. Krynitsky, J.I. Rader
Journal of Chromatography A 1218, (2011), 7956-7963
4. Isolation of activity and partial characterization of large non-proteinaceous lytic allelochemicals produced by the marine dinoflagellate Alexandrium tamarense
H. Ma, B. Krock, U. Tillmann, A.Muck, N. Wielsch, A. Svatoš, A. Cembella
Harmful Algae 11, (2011), 65-72
5. Comparison of two aerosol-based detectors for the analysis of gabapentin in pharmaceutical formulations by hydrophilic interaction chromatography
S. Jia, J.H. Park, J. Lee, S.W. Kwon
Talanta 85, (2011), 2301-2306
6. Development and validation of a hydrophilic interaction chromatography-tandem mass spectrometry method with on-line polar extraction for the analysis of urinary nucleosides. Potential application in clinical diagnosis
E. Rodríguez-Gonzalo, D. García-Gómez, R. Carabias-Martínez
Journal of Chromatography A 1218, (2011) 9055-9063
7. Skeletal stem cell physiology on functionally distinct titania nanotopographies
L.E. McNamaraa, T. Sjöström, K.E.V. Burgess, J.J.W. Kim, E. Liu, S. Gordonov, P.V. Moghe, R.M. D Meek, R.O.C. Oreffo, B. Su, M.J. Dalby
Biomaterials 32, (2011), 7403-7410
8. HPLC-UV method development for fentanyl determination in rat plasma and its application to elucidate pharmacokinetic behavior after i.p. administration to rats
A.A. Almousa, R. Ikeda, M. Wada, N. Kuroda, R.K. Hanajiri, K. Nakashima
Journal of Chromatography B 879, (2011), 2941-2944
9. A 2H nuclear magnetic resonance study of the state of water in neat silica and zwitterionic stationary phases and its influence on the chromatographic retention characteristics in hydrophilic interaction high-performance liquid chromatography
E. Wikberg, T. Sparrman, C. Viklund, T. Jonsson, K.Irgum
Journal of Chromatography A 1218, (2011), 6630-6638
10. Characterisation and stability studies of a hydrophilic decapeptide in different adjuvant drug delivery systems: A comparative study of PLGA nanoparticles versus chitosan-dextran sulphate microparticles versus DOTAP-liposomes
A. Wieber, T. Selzer, J. Kreuter
International Journal of Pharmaceutics 421, (2011), Pages 151-159
11. Zwitterionic-type hydrophilic interaction nano-liquid chromatography of complex and high mannose glycans coupled with electrospray ionisation high resolution time of flight mass spectrometry
L. Mauko, M. Pelzing, S. Dolman, A. Nordborg, N.A. Lacher, P.R. Haddad, E.F. Hilder
Journal of Chromatography A 1218, (2011), 6419-6425
12. Probing the interaction mode in hydrophilic interaction chromatography
N.P. Dinh, T. Jonsson, K. Irgum
Journal of Chromatography A 1218, (2011), 5880-5891
13. Zwitterionic hydrophilic interaction liquid chromatography (ZIC-HILIC and ZIC-cHILIC) provide high resolution separation and increase sensitivity in proteome analysis
S. Di Palma, P.J. Boersema,A.J.R. Heck,S. Mohammed
Analytical Chemistry 83, (2011), 3440-3447
14. Chromatographic characterization of hydrophilic interaction liquid chromatography stationary phases: Hydrophilicity, charge effects, structural selectivity, and separation efficiency
Y. Kawachi, T. Ikegami, H. Takuboa, Y. Ikegami, M. Miyamoto, N. Tanaka
Journal of Chromatography A 1218, (2011), 5903-5919
15. Investigations on the chromatographic behaviour of zwitterionic stationary phases used in hydrophilic interaction chromatography
R.I. Chirita, C. West, S. Zubrzyckia, A.L. Finaru, C. Elfakir
Journal of Chromatography A 1218,(2011), 5939-5963
16. Application of hydrophilic interaction chromatography for the analysis of polar contaminants in food and environmental samples
A.L.N. van Nuijs, I. Tarcomnicu, A. Covaci
Journal of Chromatography A, 1218, (2011), 5964-5974
17. Hydrophilic interaction chromatography of nucleoside triphosphates with temperature as a separation parameter
E. Johnsen, S.R. Wilson, I. Odsbu, A. Krapp, H. Malerod, K. Skarstad, E. Lundanes
Journal of Chromatography A 1218,(2011), 5981-5986
18. Free amino acids in atmospheric particulate matter of Venice, Italy
E. Barbaro, R. Zangrando, I. Moret, C.Barbante, P. Cescon, A. Gambaro
Atmospheric Environment 45,(2011), 5050-5057
19. Mode of action of membrane-disruptive lytic compounds from the marine dinoflagellate Alexandrium tamarense
H. Ma, B. Krock, U. Tillmann, U. Bickmeyer, M. Graeve, A. Cembella
Toxicon 58, (2011), 247-258
20. Screening method for the analysis of antiviral drugs in poultry tissues using zwitterionic hydrophilic interaction liquid chromatography/tandem mass spectrometry
D. Chan, J. Tarbin, M. Sharman, M. Carson, M. Smith, S. Smith
Analytica Chimica Acta 700, (2011), 194-200
21. Quantification of reduced and oxidized thiols in mouse serum by column-switching hydrophilic interaction chromatography coupled with mass spectrometry
Y. Iwasaki, Y. Nakano, K. Mochizuki, T. Ogawa, M. Oda, R. Ito, K. Saito, H. Nakazawa
Journal of Pharmaceutical and Biomedical Analysis 56, (2011), 103-113
22. Development of a molecularly imprinted polymer for selective extraction followed by liquid chromatographic determination of sitagliptin in rat plasma and urine
R.N. Rao, P.K. Maurya, S. Khalid
Talanta 85,(2011), 950-957
23. Analysis of oligonucleotides by hydrophilic interaction liquid chromatography coupled to negative ion electrospray ionization mass spectrometry
L. Gong, J.S.O. McCullagh
Journal of Chromatography A 1218,(2011), 5480-5486
24. No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid
C.B. Stine, R. Reimschuessel, C.M. Gieseker, E.R. Evans, T.D. Mayer, N.R. Hasbrouck, E. Tall, J. Boehmer, G. Gamboa da Costa, J.L. Ward
Regulatory Toxicology and Pharmacology 60, (2011), 363-372
25. Evaluation of different column types for the hydrophilic interaction chromatographic separation of iron-citrate and copper-histidine species from plants
J. Köster, R. Shi, N. von Wirén, G. Weber
Journal of Chromatography A 1218, (2011), 4934-4943
26. Microwave-assisted extraction and determination of cyanuric acid residue in infant formula samples by liquid chromatography-tandem mass spectrometry
C. Han, C. Liu, Y. Zhou, B. Xia, Z. Zhu, X.Lei, Y. Shen
Food Chemistry 127, (2011), 875-879

27. Toward Global Metabolomics Analysis with Hydrophilic Interaction Liquid ChromatographyMass Spectrometry: Improved Metabolite Identification by Retention Time Prediction
D.J. Creek, A. Jankevics, R. Breitling, D.G. Watson, M.P. Barrett, K.E.V. Burgess
Anal. Chem. 83, (2011) 8703-8710
28. Study of retention behaviour and mass spectrometry compatibility in zwitterionic hydrophilic interaction chromatography for the separation of modified nucleosides and nucleobases
E. Rodríguez-Gonzalo, D. García-Gómez, R. Carabias-Martínez
Journal of Chromatography A 1218,(2011), 3994-4001
29. Determination of catecholamines in urine using hydrophilic interaction chromatography with electrochemical detection
A. Kumar, J.P. Hart, D.V. McCalley
Journal of Chromatography A. 1218 (2011) 3854-3861
30. Screening and confirmatory methods for the determination of melamine in cow s milk and milk-based powdered infant formula: Validation and proficiency-tests of ELISA, HPLC-UV, GC-MS and LC-MS/MS
P. Lutter, M.C. Savoy-Perroud, E. Campos-Gimenez, L. Meyer, T. Goldmann, M.C. Bertholet, P. Mottier, A. Desmarchelier, F. Monard, C. Perrin, F. Robert, T. Delatour
Food Control 22, (2011) 903-913
31. Hydrophilic interaction liquid chromatography in food analysis
J. Bernal, A.M. Ares, J. Pól, S.K. Wiedmer
Journal of Chromatography A, 1218 (2011) 7438-7452
32. Surface modification of TiO2 for selective photodegradation of toxic compounds
Y. Tominaga, T. Kubo, K. Hosoya
Catalysis Communications, 12, (2011), 785-789
33. Sulfation of the 3,4-methylenedioxymethamphetamine (MDMA) metabolites 3,4-dihydroxymethamphetamine (DHMA) and 4-hydroxy-3-methoxymethamphetamine (HMMA) and their capability to inhibit human sulfotransferases
A.E. Schwaninger, M.R. Meyer, J. Zapp, H.H. Maurer
Toxicology Letters,202,(2011), 120-128
34. Development and validation of a highly sensitive LC-MS/MS method for organic cation transporter (OCT) substrate tetraethylammonium (TEA) in rabbits
J. Nirmal, T. Velpandian, S. Baskar Singh, N.R. Biswas, V. Thavaraj, R. Azad, S. Ghose
Journal of Chromatography B, 879, (2011), 585-590
35. Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy
J. Tchekalarova, D. Pechlivanova, T. Atanasova, P. Markova, V. Lozanov, A. Stoynev
Epilepsy & Behavior, 20, (2011), 277-285
36. Water ingestion during water recreation
S. Dorevitch, S. Panthi, Y. Huang, H. Li, A.M. Michalek, P. Pratap, M. Wroblewski, L. Liu, P.A. Scheff, A. Li
Water Research, 45, (2011), 2020-2028
37. Development and validation of a high-throughput double solid phase extraction-liquid chromatography-tandem mass spectrometry method for the determination of tetrodotoxin in human urine and plasma
B.M.W Fong, S. Tam, S.H Tsui, K.S.Y Leung
Talanta 83, (2011) 1030-1036
38. Hydrophilic Interaction Chromatography (HILIC) in the Analysis of Relevant Quality and Safety Biochemical Compounds in Meat, Poultry and Processed Meats
L. Mora, A.S. Hernandez-Cazares, M.C. Aristoy, F Toldra, M. Reig
Food Anal. Meth. 4 (2011) 121-129
39. Metabolomic profiling of biomarkers of liver X receptor-induced toxicity in mouse liver tissue
L. MacIntyre, L.A. Zheng LA, P. Scullion, P. Keating, D.G. Watson DG
Metabolomics 7 (2011) 54-70
40. A Novel Multidimensional Protein Identification Technology Approach Combining, Protein Size Exclusion Prefractionation, Peptide Zwitterion-Ion Hydrophilic Interaction Chromatography, and Nano-Ultraperformance RP Chromatography/nESI-MS2 for the in-Depth Analysis of the Serum Proteome and Phosphoproteome: Application to Clinical Sera Derived from Humans with Benign Prostate Hyperplasia
S.D. Garbis, T.I. Roumeliotis, S.I. Tyritzis, K.M. Zorpas, K. Pavlakis, C.A. Constantinides
Anal. Chem. 83 (2011) 708-718
41. Hydrophilic interaction liquid chromatography in the separation of a moderately lipophilic drug from its highly polar metabolites-The cardioprotectant dexrazoxane as a model case
P. Kovarikova, J. Stariat, J. Klimes, K. Hruskova, K. Vavrova,
J. Chromatogr. A 1218 (2011) 416-426 

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1. Speciation of gadolinium based MRI contrast agents in environmental water samples using hydrophilic interaction chromatography hyphenated with inductively coupled plasma mass spectrometry
C.S.K. Raju, A. Cossmer, H. Scharf, U. Panne, D. Luck
J. Anal. At. Spectrom.,25 (2010) 55-61
2. Effects of the operation parameters on Hydrophilic Interaction Liquid Chromatography separation of phenolic acids on zwitterionic monolithic capillary columns
V. Skerikova, P. Jandera
J.Chromatogr. A 1217 (2010)7981-7989
3. Structure elucidation of the thermal degradation products of the nucleotide cofactors NADH and NADPH by nano-ESI-FTICR-MS and HPLC-MS
D. Hofmann, A. Wirtz, B. Santiago-Schubel, U. Disko, M. Pohl
Anal. Bioanal. Chem. 398 2010 2803-2811

4. Metabolite Identification in Synechococcus sp. PCC 7002 Using Untargeted Stable Isotope Assisted Metabolite Profiling
R. Baran, B.P. Bowen, N.J. Bouskill, E.L. Brodie, S.M. Yannone, T.R. Northen,
Anal. Chem. 82, (2010) 9034-9042

5. Glycoproteomic Profile in Wine A Sweet Molecular Renaissance
G. Palmisano, D. Antonacci, M.R. Larsen
J. Proteome res. 9 2010 6148-6159 

6. Efficient hydrophilic interaction liquid chromatography-tandem mass spectrometry for the multiclass analysis of veterinary drugs in chicken muscle
C. Chiaochan, U. Koesukwiwat, S. Yudthavorasit, N. Leepipatpiboon
Analytica Chimica acta 682 2010 117-129
7. A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes
C.P. Ward, K.E.V. Burgess, R.J.S. Burchmore, M.P. Barrett, H.P. de Koning
Molecular and Biochemical Parasitology, 174, (2010) 145-149
8. Reassessment of the toxin profile of Cylindrospermopsis raciborskii T3 and function of putative sulfotransferases in synthesis of sulfated and sulfonated PSP toxins Original Research Article
K. Soto-Liebe, A.A. Murillo, B. Krock, K. Stucken, J.J. Fuentes-Valdés, N. Trefault, A. Cembella, M. Vásquez
Toxicon, 56, (2010) 1350-1361
9. Metabolomics to Unveil and Understand Phenotypic Diversity between Pathogen Populations
R. t Kindt, R.A. Scheltema, A. Jankevics, K. Brunker, S. Rijal, J.C. Dujardin, R. Breitling, D.G. Watson, G.H. Coombs, S. Decuypere
10. Biological monitoring of occupational exposure to 5-fluorouracil: Urinary alpha-fluoro-beta-alanine assay by high performance liquid chromatography tandem mass spectrometry in healt care personnel S. Ndaw, F. Denis, P. Marsan, A. d Almeida, A. Robert A
J. Chrom. B, 878 2010 Issue: 27, Sp. Iss. SI 2630-2634
11. Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis
R. t Kindt, A. Jankevics, R.A. Scheltema, L.A. Zheng, D.G. Watson, J.C. Dujardin, R. Breitling, G.H. Coombs, S. Decuypere
Anal. Bioanal. chem. 398 2010 2059-2069
12. Detection of hazelnut oil in extra-virgin olive oil by analysis of polar components by micro-solid phase extraction based on hydrophilic liquid chromatography and MALDI-ToF mass spectrometry
C.D. Calvano, A. Aresta, C.G.Zambonin
J. Mass spec. 45 2010 981-988
13. Glycosylation Analysis by Dedicated Sample Preparation and Complementary nano-LC (HILIC/RP)/ESI-MS
J. Wohlgemuth, W. Jiang, E. Machtejevas
LC GC NORTH AMERICA SEP 2010 17-17 Suppl. S
14. Determination of aromatic amines in aqueous extracts of polyurethane foam using hydrophilic interaction liquid chromatography and mass spectrometry
J. Riddar Johnson, D. Karlssona, M. Dalenea, G. Skarping
Analytica Chimica Acta 678, (2010) 117-123
15. Direct Determination of Ethyl Glucuronide and Ethyl Sulfate in Postmortem Urine Specimens Using Hydrophilic Interaction Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry
A.I. Al-Asmari, R.A. Anderson, P. Appelblad
J. Anal. Tox. 34 (2010) 261-272
16. Glycan profiling of monoclonal antibodies using zwitterionic-type hydrophilic interaction chromatography coupled with electrospray ionization mass spectrometry detection
L. Mauko, A. Nordborg, J. P. Hutchinson, N. A. Lacher, E. F. Hilder, P. R. Haddad
Anal. Biochem., 408 (2011) 235-241  

17. Development of a new method using HILIC-tandem mass spectrometry for the characterization of O-sialoglycopeptides from proteolytically digested caseinomacropeptide.
O. Hernandez-Hernandez, R. Lebron-Aguilar, J.E. Quintanilla-Lopez, M. L. Sanz, F.J. Moreno
Proteomics, 10 (2010) 3699-3711

18. Evidence for saxitoxins production by the cyanobacterium Aphanizomenon gracile in a French recreational water body Original Research Article
A. Ledreux, S. Thomazeau, A. Catherine, C. Duval, C. Yéprémian, A. Marie, C. Bernard
Harmful Algae, 10, (2010) 88-97

19. Approach to hydrophilic interaction chromatography column selection: Application to neurotransmitters analysis.
R.-I. Chiritaa, C. Westa, A.-L. Finarub and C. Elfakir
J. Chromatogr. A. 1217 (2010) 3091-3104
20. Metabolomic applications of HILIC-LC-MS.
S. Cubbon, C. Antonio, J. Wilson, J. Thomas-Oates
Mass Spectrom. Rev., 29 (2010) 671-684
21. Hydrophilic interaction chromatographic determination of adenosine triphosphate and its metabolites.
L. Moraa, A.S. Hernández-Cázaresa, M.C Aristoya, F. Toldrá
Food Chemistry 123 (2010) 1282-1288
22.  Stability of 5-Fluoro-2-deoxycytidine and Tetrahydrouridine in Combination.
D.L. Guo, P.B. Myrdal, K.L. Karlage, S.P. O Connell, T.J. Wissinger, S.E. Tabibi, S.H. Yalkowsky
AAPS PHARMSCITECH, 11 (2010) 247-252

23. Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry.
L.A. Zheng, R. T´Kind, S. Decuypere, S.J. von Freyend, G.H. Coombs, D.G. Watson
Rapid Comun. Mass Spec., 2010, 24, 2074-2082

24. Pheomelanin-related benzothiazole isomers in the urine of patients with diffuse melanosis of melanoma.
D.N. Dernroth, K. Arstrand, G. Greco, L. Panzella, A. Napolitano, B. Kagedal
Clin. Chim. Acta, 2010, 411, 1195-1203

25. Utilizing Ion-Pairing Hydrophilic Interaction Chromatography Solid Phase Extraction for Efficient Glycopeptide Enrichment in Glycoproteomics
S. Mysling, G Palmisano, P. Hojrup,M. Thaysen-Andersen
Anal. Chem. 2010, 82, 5598-5609

26.  Multiclass, Multiresidue Drug Analysis, Including Aminoglycosides, in Animal Tissue Using Liquid Chromatography Coupled to Tandem Mass Spectrometry
P.A. Martos, F. Jayasundara, J. Dolbeer, W. Jin, L. Spilsbury, M. Mitchell, C. Varilla, B. Shurmer
J. Agric. Food Chem., 58 (2010) 5932-5944

27. Hydrophilic interaction LC of peptides: Columns comparison and clustering
S. Van Dorpe, V. Vergote, A. Pezeshki, C. Burvenich, K. Peremans, B. De Spiegeleer
J. Sep. Sci. 2010, 33, 728-739

28. Hydrophilic interaction chromatography coupled to MS for metabonomic/metabolomic studies
K. Spagou, H. Tsoukali, N. Raikos, H.Gika, I. D. Wilson, G. Theodoridis
J. Sep. Sci. 2010, 33, 716-727

29. Enhanced glyco-profiling by specific glycopeptide enrichment and complementary monolithic nano-LC (ZIC-HILIC/RP18e)/ESI-MS analysis
J. Wohlgemuth, M. Karas, W.Jiang, R. Hendriks, S. Andrecht
J. Sep. Sci. 2010, 33, 880-890

30. Characterization of sialylated and fucosylated glycopeptides of 2-glycoprotein I by a combination of HILIC LC and MALDI MS/MS
Kondo, M. Thaysen-Andersen, K. Hjernø, O. N. Jensen
J. Sep. Sci. 2010, 33, 891-902

31. Lactic acid quantitation in hand dishwashing liquid using an HILIC-UV methodology
M. Storton, J. Exarchakis, T. Waters, Z. Hao , B.Parker, M. Knapp
J. Sep. Sci. 2010, 33, 982-987

32. Multitarget quantitative metabolic profiling of hydrophilic metabolites in fermentation broths of β-lactam antibiotics production by HILIC-ESI-MS/MS
S. Schiesel, M. Lämmerhofer, W. Lindner
Anal Bioanal Chem (2010) 396:1655-1679

33. 2-D hydrophilic interaction liquid chromatography-RP separation in urinary proteomics - Minimizing variability through improved downstream workflow compatibility
H. Loftheim, T. D. Nguyen, H. Malerød, E. Lundanes, A. Åsberg, L. Reubsaet
J. Sep. Sci. 2010, 33, 864-872

34. Dual hydrophilic interaction-RP retention mechanism on polar columns: Structural correlations and implementation for 2-D separations on a single column
P. Jandera, T. Hájek, V. Škeříková, J. Soukup
J. Sep. Sci. 2010, 33, 841-852

35. Hydrophilic stationary phases: A practical approach for the co-analysis of compounds with varying polarity in biological matrices
E. Goucher, A. Kicman, K. Wolff, N. Smith, S. Jickells
J. Sep. Sci. 2010, 33, 955-965

36. Detection of the neurotoxin BMAA within cyanobacteria isolated from freshwater in China
A. Li, Z. Tian, J. Li, R. Yu, S.A. Banack, Z. Wang
Toxicon, 55, (2010) 947-953

37. Determination of melamine in milk powder using zwitterionic HILIC stationary phase with UV detection
F.I. Nkem, S. Tesfalidet, W. Jiang
J. Sep. Sci., 33 (2010) 988-995

38. Hydrophilic interaction LC combined with electrospray MS for highly sensitive analysis of underivatized amino acids in rhizosphere research
M. Dell mour, L. Jaitz, E. Oburger, M. Puschenreiter, G. Koellensperger, S. Hann
J. Sep. Sci., 33 (2010) 911-922

39. Separation of purine and pyrimidine bases and nucleosides by hydrophilic interaction chromatography
G. Marrubini, B.E. Mendoza, G. Massolini
J. Sep. Sci., 33 (2010) 803-816

40. Retention of arsenic species on zwitterionic stationary phase in hydrophilic interaction chromatography
D. Xie, J. Mattusch, R. Wennrich
J. Sep. Sci., 33 (2010) 817-825

41. Hydrophobicity/hydrophilicity descriptors obtained from extrapolated chromatographic retention data as modeling tools for biological distribution: Application to some oxime-type acetylcholinesterase reactivators
V. Voicu, I. Sorac, C. Sârbud, V. Davide, A. Medvedovici
J. Pharm. Biomed. Anal. 52(4), 2010, 508-516

42. Hydrophilic interaction liquid chromatography/positive ion electrospray ionization mass spectrometry method for the quantification of perindopril and its main metabolite in human plasma
S. Georgakakou, M. Kazanis, I. Panderi
Anal. Bioanal. Chem., 397(6), 2010, 2161-2170

43. Metabolic profiling of intracellular metabolites in fermentation broths from ?-lactam antibiotics production by liquid chromatography-tandem mass spectrometry methods
B. Preinerstorfer, S. Schiesel, M. Lämmerhofer, W. Lindner
J. Chromatogr. A, 1217 (2010) 312-328

44.  The glycosylation and characterization of the candidate Gc macrophage activating factor
T. Ravnsborg, D.T. Olsen, A. Hammerich Thysen, M. Christiansen, G. Houen, P. Højrup
Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1804, (2010), 909-917

45. Creatine and Creatinine Evolution during the Processing of Dry-Cured Ham
L. Mora, A. S. Hernandez-Cázares, M. A. Sentandreu, F. Toldrá
Meat Sci., 84, (2010), 384-389

46. Polymethacrylate monolithic and hybrid particle-monolithic columns for reversed-phase and hydrophilic interaction capillary liquid chromatography
P. Jandera, J. Urban, V. Škeříková, P. Langmaier, R. Kubíčková, J. Planeta
J. Chromatogr. A, 1217, (2010), 22-33

47. Development and application of an LC-MS/MS method for measuring the effect of (partial) agonists on cAMP accumulation in vitro
W. Goutier, P.A. Spaans, M.A.W van der Neut, A.C. McCreary, J.H. Reinders
J. Neurosci. Meth. 188 (2010) 24-31
48. LC-MS/MS determination of the isomeric neurotoxins BMAA (β-N-methylamino-l-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius
T. Krüger, B. Mönch, S. Oppenhäuser, B. Luckas
Toxicon 55, (2010), 547-557
49. Ganoderma species discrimination by dual-mode chromatographic fingerprinting: A study on stationary phase effects in hydrophilic interaction chromatography and reduction of sample misclassification rate by additional use of reversed-phase chromatography
Y. Chen, W. Bicker, J.Y. Wu, M.Y. Xie, W. Lindner
J. Chrom. A 1217 (2010) 1255-1265
50. Evaluation of cell lysis methods for platinum metallomic studies of human malignant cells
M.Q. Thanh Tran, Y. Nygren, C. Lundin, P. Naredi, E. Björn.
Analytical Biochemistry 396, (2010), 76-82

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1. Rapid analysis of GABA and glutamate in microdialysis samples using high performance liquid chromatography and tandem mass spectrometry
K. Buck, P. Voehringer, B. Ferger,
Journal of Neuroscience Methods 182, (2009) 78-84
2. Direct injection horse-urine analysis for the quantification and confirmation of threshold substances for doping control. IV, Determination of 3-methoxytyramine by hydrophilic interaction liquid chromatography/quadrupole time-of-flight mass spectrometry A. Vonaparti, E. Lyris, I. Panderi, M. Koupparis,  C. Georgakopoulos

3. Proteomic analysis of membrane proteins expressed specifically in pluripotent murine embryonic stem cells
A. Intoh, A. Kurisaki, Y. Yamanak, H. Hirano, H. Fukuda, H. Sugino, M. Asashima
PROTEOMICS 9 (2009) 126-137

4. Evaluation of cell lysis methods for platinum metallomic studies of human malignant cells
M. Q. Thanh Tran, Y. Nygren, C. Lundin, P. Naredi, E. Björn
Anal. Biochem., 396(1), 2009, 76-82

5. Glycopeptide profiling of beta-2-glycoprotein I by mass spectrometry reveals attenuated sialylation in patients with antiphospholipid syndrome
A. Kondo, T. Miyamoto, O. Yonekawa, A. M. Giessing, E. C. Østerlunda, O. N. Jensen
J. Proteomics. 73 (2009),123-133

6. Application of amino acid analysis using hydrophilic interaction liquid chromatography coupled with isotope dilution mass spectrometry for peptide and protein quantification
M. Kato, H. Kato, S. Eyama, A. Takatsu
J. Chromatogr. B, 877 (2009) 3059–64

7. Determination of inorganic pharmaceutical counterions using hydrophilic interaction chromatography coupled with a Corona® CAD detector
Z. Huang, M.A. Richards, Y. Zha, R. Francis, R. Lozano, J. Ruan
J. Pharm. Biomed. Anal., 50 (2009) 809–814

8. Methods for Detection of Anatoxin-a(s) by Liquid Chromatography Coupled to Electrospray Ionization-Tandem Mass Spectrometry
F. A. Dörr, V. Rodriguez, R. Molica, P. Henriksen, B. Krock, E. Pinto
Toxicon, 55(1), 2009, 92-99

9. Occurrence and composition of extracellular lipids and polysaccharides in a full-scale membrane bioreactor
D. Al-Halbounia, W. Dotta, J. Hollender
Water Res., 43 (2009) 97–106

10. Quantitative Site-Specific Analysis of Protein Glycosylation by LC-MS Using Different Glycopeptide Enrichment Strategies
J. Wohlgemuth, M. Karas, T. Eichhorn, R. Hendriks, S. Andrecht
Anal. Biochem., 395 (2009) 178-188

11. Toxicokinetics of Acrylamide in Rats and Humans Following Single Oral Administration of Low Doses
E. K. Kopp, W. Dekant
Toxicol. Appl. Pharmacol., 235 (2009) 135–142

12. Liquid Chromatography/Tandem Mass Spectrometry of Glycolytic Intermediates: Deconvolution of Coeluting Structural Isomers Based on Unique Product Ion Ratios
K.L. Ross, J.J. Dalluge
Anal. Chem. 81, (2010) 4021-4026
13. Site-Specific Glycoprofiling of N-Linked Glycopeptides Using MALDI-TOF MS: Strong Correlation between Signal Strength and Glycoform Quantities
M. Thaysen-Andersen, S. Mysling, P. Højrup
Anal. Chem. 81, (2009) 3933-3943

14. Speciation Analysis of Gadolinium Chelates in Hospital Effluents and Wastewater Treatment Plant Sewage by a Novel HILIC/ICP-MS Method
J. Kunnemeyer, L. Terborg, B. Meermann, C. Brauckmann, I.M.A. Scheffer, U. Karst
Environmental Sci. Tech. 43 (2009) 2884-2890

15. Hydrophilic Interaction Liquid Chromatography with Alcohol as a Weak Eluent
M. Liu, J. Ostovica, E. Chena, N. Cauchona
J. Chromatogr. A., 1216 (2009) 2362-70

16. Application of HILIC stationary phase to determination of dimethindene maleate in topical gel
L. Matysová, L. Havlíková, R. Hájková, A. Krivda, P. Solich
Journal of Pharmaceutical and Biomedical Analysis 50 (2009) 23-26

17. Characteristics of Transport of Selenoamino Acids by Epithelial Amino Acid Transporters
A. Nickel, G. Kottra, G. Schmidt, J. Danier, T. Hofmann, H. Daniel
Chemico-Biological Interactions, 177 (2009) 234-241

18. Challenge of High Polarity and Low Concentrations in Analysis of Cytostatics and Metabolites in Wastewater by Hydrophilic Interaction Chromatography/Tandem Mass Spectrometry
L. Kovalova, C. S. McArdell, J. Hollender
J. Chromatogr. A, 1216 (2009) 1100-1108

19. Towards a platform for the metabonomic profiling of different strains of Drosophila melanogaster using liquid
chromatography-Fourier transform mass spectrometry
M.A. Kamleh, Y. Hobani, J.A.T. Dow, L. Zheng, D.G. Watson
FEBS Journal 276 (2009) 6798-6809

20. Simultaneous Determination of Three Anticonvulsants using Hydrophilic Interaction LC-MS
R. Oertel, N. Arenz, J. Pietsch, W. Kirch
J. Sep. Sci., 32 (2009) 238-243 

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1. Separation efficiencies in hydrophilic interaction chromatography
T. Ikegami T, K. Tomomatsu, H. Takubo, K. Horie, N.Tanaka
J. Chromatogr. A 1184 (2008) 474-503
2. Multi-residue quantitation of aminoglycoside antibiotics in kidney and meat by liquid chromatography with tandem mass spectrometry
R. Ishii, M. Horie, W. Chan, J. MacNeil
Food Add.Contam. A. 25 (2008) 1509-1519
3. Separation with zwitterionic hydrophilic interaction liquid chromatography improves protein identification by matrix-assisted laser desorption/ionization-based proteomic analysis
A. Intoh, A. Kurisaki, H. Fukuda, M. Asashima
BIOMED. CHROM. 23 (2009) 607-614
4. Protein Quantification by Isotope Dilution Mass Spectrometry of Proteolytic Fragments: Cleavage Rate and Accuracy
C.G. Arsene, R. Ohlendorf, W. Burkitt, C. Pritchard, A. Henrion, G. O Connor, D.M. Bunk, B. Guttler
Anal. Chem. 2008, 80, 4154-4160

5. Trace analysis of dithiocarbamate fungicide residues on fruits and vegetables by hydrophilic interaction liquid chromatography/tandem mass spectrometry
G. Crnogorac, S. Schmauder, W. Schwack
Rapid Commun. Mass Spectrom., 22 (2008) 2539-2546

6. Separation of Organoarsenicals by Means of Zwitterionic Hydrophilic Interaction Chromatography (ZIC (R)-HILIC) and Parallel ICP-MS/ESI-MS Detection
D. Xie, J. Mattusch, R. Wennrich
Eng. Life Sci., 8 (2008) 582-588

7. Determination of the neurotoxin BMAA (b-N-methylamino-L-alanine) in cycad seed and cyanobacteria by LC-MS/MS
J. Rosén and K-E. Hellenäs
Analyst, 2008, 133, 1785–1789

8. Optimization of Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry and Development of Solid-Phase Extraction for the Determination of Paralytic Shellfish Poisoning Toxins.
E. Turrell, L. Stobo, J.P. Lacaze, S. Piletsky, E. Piletska.
J. AOAC Int., 91 (2008) 1372-1386

9. Development and Validation of a High-Throughput Zwitterionic Hydrophilic Interaction Liquid Chromatography Solid-Phase Extraction-Liquid Chromatography-Tandem Mass Spectrometry Method for Determination of the Anti-Influenza Drug Peramivir in Plasma
N. Lindegardh, W. Hanpithakpong, A. Phakdeeraj, P. Singhasivanon, J. Farrar, T.T. Hien, N.J. White, N.P.J. Day
J. Chromatogr. A, 1215 (2008) 145-151

10. The Determination of Iron as its EDTA Complex in Helix Aspera by Hydrophilic Interaction Liquid Chromatography Coupled to Fourier Transform Electrospray Ionisation Mass Spectrometry
L. Zheng, D.G.Watson, J.N.A. Tettey, C.A. Clements
Talanta, 76 (2008) 1165-1169

11. Application of Hydrophilic Interaction Chromatography for Simultaneous Separation of Six Impurities of Mildronate Substance
J. Hmelnickis, O. Pugovics, H. Kazoka, A. Viksna, I. Susinskis, K. Kokums
J. Pharm. Biomed. Anal., 48 (2008) 649-656

12. Rapid and Sensitive HILIC-ESI-MS/MS Quantitation of Polar Metabolites of Acrylamide in Human Urine Using Column Switching with an Online Trap Column
E.K. Kopp, M. Sieber, M. Kellert and W. Dekant
J. Agric. Food Chem., 56 (2008) 9828-9834

13. Assessment of Lectin and HILIC Based Enrichment Protocols for Characterization of Serum Glycoproteins by Mass Spectrometry
Cosima D. Calvano, Carlo G. Zambonin, Ole N. Jensen
J. Proteomics, 71 (2008) 304-317

14. Speciation Analysis of Gadolinium-Based MRI Contrast Agents in Blood Plasma by Hydrophilic Interaction Chromatography- Electrospray Mass Spectrometry
J. Künnemeyer, L. Terborg, S. Nowak, A. Scheffer, L. Telgmann, F. Tokmak, A. Günsel, G. Wiesmüller,S. Reichelt and U. Karst
Anal. Chem., 80 (2008) 8163-8170

15. Column-Switching Reversed Phase-Hydrophilic Interaction Liquid Chromatography/Tandem Mass Spectrometry Method for Determination of Free Estrogens and their Conjugates in River Water
Feng Qin, Yuan Yuan Zhao, Michael B. Sawyer, Xing-Fang Li
Anal. Chim. Acta, 627 (2008) 91-98

16. Quantification of Methylmalonic Acid in Human Plasma with Hydrophilic Interaction Liquid Chromatography Separation and Mass Spectrometric Detection
H-A Lakso, P. Appelblad, J. Schneede
Clin. Chem., 54 (2008) 2028

17. Simultaneous Determination and Confirmation of Melamine and Cyanuric Acid in Animal Feed by Zwitterionic Hydrophilic Interaction Chromatography and Tandem Mass Spectrometry.
D. N. Heller, C. B. Nochetto
Rapid. Commun. Mass Spectrom, 22 (2008) 3624-3632

18. Oseltamivir Is Adequately Absorbed Following Nasogastric Administration to Adult Patients with Severe H5N1 Influenza
W. R. J. Taylor, B. N. Thinh, G. T. Anh, P. Horby, H. Wertheim, N. Lindegårdh, M. D. de Jong, K. Stepniewska, T. T. Hanh, N. D. Hien, N. M. Bien, N. Q. Chau, A. Fox, N. M. Ngoc, M. Crusat, J. J. Farrar, N. J. White, N. H. Ha, T. T. Lien, N. V. Trung, N. Day, N. G. Binh
PLoS ONE, 3 (2008) e3410 online open access

19. Toxin-screening and identification of bacteria isolated from highly toxic marine gastropod Nassarius semiplicatus
X.J. Wang, R.C. Yu, X. Luo, M.J. Zhou, X.T. Lin
Toxicon 52, (2008), 55-61

20. Metabolomic Profiling of Drosophila Using Liquid
Chromatography Fourier Transform Mass Spectrometry
M.A. Kamleh, Y. Hobani, J.A.T. Dow, D.G. Watson
FEBS Letters, 582 (2008) 2916-2922

21. Metabolomic Profiling using Orbitrap Fourier Transform Mass Spectrometry with Hydrophilic Interaction Chromatography: A Method with Wide Applicability to Analysis of Biomolecules
A. Kamleh, M. P. Barrett, D. Wildridge, R. J. S. Burchmore, R. A. Scheltema, D. G. Watson
Rapid Commun. Mass Spectrom., 22 (2008) 1912-1918

22. Fast Hydrophilic Interaction Liquid Chromatographic Separations on Bonded Zwitterionic Stationary Phase
P. Appelblad, T. Jonsson, W. Jiang, K. Irgum
J. Sep. Sci., 31 (2008) 1529-1536

23. Method Development for HILIC Assays
B. Dejaegher, D. Mangelings, Y. Vander Heyden
J. Sep. Sci., 31 (2008) 1438-1448

24. Chromatographic Deuterium Isotope Effects of Derivatized N-Glycans and N-Glycopeptides in a Zwitterionic Type of Hydrophilic Interaction Chromatography.
Y. Takegawa, M. Hatou, K. Deguchi, H. Nakagawa, S.-I. Nishimura
J. Sep. Sci., 31 (2008) 1594-1597

25. Profiling of N- and O-Glycopeptides of Erythropoietin by Capillary Zwitterionic-Type of Hydrophilic Interaction Chromatography/Electrospray Ionization Mass Spectrometry.
Y. Takegawa, H. Ito, T. Keira, K. Deguchi, H. Nakagawa, S.-I. Nishimura
J. Sep. Sci., 31 (2008) 1585-1593

26. Hydrophilic Interaction Liquid Chromatography (HILIC) Coupled to Inductively Coupled Plasma Mass Spectrometry (ICPMS) utilizing a Mobile Phase with a Low-Volatile Organic Modifier for the Determination of Cisplatin, and its Monohydrolyzed Metabolite
Y. Nygren, P. Hemström, C. Åstot, P. Naredi, E. Björn
J. Anal. At. Spectrom., 23 (2008) 948-954

27. Hydrophilic Interaction Chromatography of Small Metal Species in Plants using Sulfobetaine- and Phosphorylcholine-Type Zwitterionic Stationary Phases
G. Weber, N. von Wirén, H. Hayen
J. Sep. Sci., 31 (2008) 1615-1622

28. Potential of HILIC-MS in Quantitative Bioanalysis of Drugs and Drug Metabolites
Y. Hsieh
J. Sep Sci., 31 (2008) 1481-1491

29. Stationary Phases for Hydrophilic Interaction Chromatography, their Characterization and Implementation into Multidimensional Chromatography Concepts
P. Jandera
J. Sep Sci., 31 (2008) 1421-1437

30. Hydrophilic Interaction Liquid Chromatography Method for the Determination of Ascorbic Acid
L. Nováková, D. Solichová, S. Pavloviová, P. Solich
J. Sep. Sci., 31 (2008) 1634-1644

31. Quantification of Acetylcholine in Microdialysate of Subcutaneous Tissue by Hydrophilic Interaction Chromatography/Tandem Mass Spectrometry
B. Fu, X. Gao, S. P. Zhang, Z. Cai and J. Shen
Rapid Commun. Mass Spectrom., 22 (2008) 1497–1502

32. Alternative Organic Solvents for HILIC Separation of Cisplatin Species with On-Line ICP-MS Detection
P. Hemström, Y. Nygren, E. Björn, K. Irgum
J. Sep. Sci., 31 (2008) 599-603

33. Two-Dimensional Hydrophilic Interaction Chromatography Coupling Anion Exchange and Hydrophilic Interaction Columns for Separation of 2-Pyridylamino Derivatives of Neutral and Sialylated N-Glycans.
K. Deguchi, T. Keira, K. Yamada, H. Ito, Y. Takegawa, H. Nakagawa, S.-I. Nishimura
J. Chromatogr. A, 1189 (2008) 169-174

34. Hydrophilic Interaction Chromatography/Electrospray Mass Spectrometry Analysis of Carbohydrate-Related Metabolites from Arabidopsis thaliana Leaf Tissue
C. Antonio, T. Larson, A. Gilday, I. Graham, E. Bergström, J. Thomas-Oates
Rapid Commun. Mass Spectrom., 22 (2008) 1399-1407

35. Improving the Resolution of Neuropeptides in Rat Brain with On-Line HILIC-RP Compared to On-line SCX-RP
1. Mihailova, H. Malerød, S. R. Wilson, B. Karaszewski, R. Hauser, E. Lundanes, T. Greibrokk
J. Sep. Sci., 31 (2008) 459-467

36. Experimental Determination of LSER Parameters for a Set of 76 Diverse Pesticides and Pharmaceuticals
H. C. Tülp, K.-U. Goss, R. P. Schwarzenbach, K. Fenner
Environ. Sci. Technol., 42 (2008) 2034–2040

37. Retention of Opioids and their Glucuronides on a Combined Zwitterion and Hydrophilic Interaction Stationary Phase
S. Vikingsson, R. Kronstrand, M. Josefsson
J. Chromatogr. A, 1187 (2008) 46-52

38. Hydrophilic Interaction Liquid Chromatography (HILIC) in Proteomics [Review]
P. J. Boersema, S. Mohammed, A. J. R. Heck
Anal. Bioanal. Chem., (2008) online open access

39. Fast Sample Preparation and Liquid Chromatography-Tandem Mass Spectrometry Method for Assaying Cell Lysate Acetylcholine
N. H. Schebb, D. Fischer, E.-M. Hein, H. Hayen, J. Krieglstein, S. Klumpp, U. Karst
J. Chromatogr. A, 1183 (2008) 100-107

40. Investigating the Biomarker Potential of Glycoproteins using Comparative Glycoprofiling - Application to Tissue Inhibitor of Metalloproteinases-1
M. Thaysen-Andersen, I. B. Thøgersen, U. Lademann, H. Offenberg, A. M. B. Giessing, J. J. Enghild, H. J. Nielsen, N. Brünner, P. Højrup
Biochim. Biophys. Acta, 1784 (2008) 455-463 

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1. Determination of Dithiocarbamate Fungicide Residues by Liquid Chromatography/Mass Spectrometry and Stable Isotope Dilution Assay
G. Crnogorac, W. Schwack
Rapid Commun. Mass Spectrom., 21 (2007) 4009-4016
2. Comparative Evaluation of High-Performance Liquid Chromatography Stationary Phases Used for the Separation of Peptides in Terms of Quantitative Structure-Retention Relationships
M. Michel, T. Baczek, S. Studzinska, K. Bodzioch, T. Jonsson, R. Kaliszan, B. Buseeski
J. Chromatogr. A, 1175 (2007) 49-54
3. Hydrophilic Interaction Chromatography for Mass Spectrometric Metabonomic Studies of Urine
S. Cubbon, T. Bradbury, J. Wilson, J. Thomas-Oates
Anal. Chem., 79 (2007) 8911-8918
4. Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective
D. B. Barr, J. R. Barr, G. Weerasekera, J. Wamsley, S. R. Kalb, A. Sjödin, J. G. Schier, E. D. Rentz, L. Lewis, C. Rubin, L. L. Needham, R. L. Jones, E. J. Sampson
J. Anal. Toxicol., 31 (2007) 295-303
5. Simultaneous Determination of 3-Nitrotyrosine, Tyrosine, Hydroxyproline and Proline in Exhaled Breath Condensate by Hydrophilic Interaction Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry
A. Conventz, A. Musiol, C. Brodowsky, A. Müller-Lux, P. Dewes, T. Kraus, T. Schettgen
J. Chromatogr. B, 860 (2007) 78-85
6. Analysis of Moniliformin in Maize Plants Using Hydrophilic Interaction Chromatography
J. L. Sørensen, K. F. Nielsen, U. Thrane
J. Agric. Food Chem., 55 (2007) 9764-9768
7. Development and Validation of a Liquid Chromatographic-Tandem Mass Spectrometric Method for Determination of Oseltamivir and its Metabolite Oseltamivir Carboxylate in Plasma, Saliva and Urine
N. Lindegårdh, W. Hanpithakpong, Y. Wattanagoon, P. Singhasivanon, N. J. White, N. P. Day
J. Chromatogr. B, 859 (2007) 74-83
8. Retention Studies of Acrylamide for the Design of a Robust Liquid Chromatographic - Tandem Mass Spectrometry Method for Food Analysis
J. Rosén, A. Nyman, K.-E. Hellenäs
J. Chromatogr. A, 1172 (2007) 19-24
9. Barley Peroxidase Isozymes Expression and Post-Translational Modification in Mature Seeds as Identified by Two-Dimensional Gel Electrophoresis and Mass Spectrometry
S. Laugesena, K. Sass Bak-Jensen, P. Hägglund, A. Henriksen, C. Finnie, B. Svensson, P. Roepstorff
Int. J. Mass Spectrom., 268 (2007) 244-253
10. Secreted Glycoprotein from Live Zaire ebolavirus-Infected Cultures: Preparation, Structural and Biophysical Characterization, and Thermodynamic Stability
L. G. Barrientos, A. M. Martin, R. M. Wohlhueter, P. E. Rollin
J. Infect. Des., 196 (2007) (Suppl. 2) S220-S231
11. 2D LC Separation and Determination of Bradykinin in Rat Muscle Tissue Dialysate with On-Line SPE-HILIC-SPE-RP-MS
S. R. Wilson, M. Jankowski, M. Pepaj, A. Mihailova, F. Boix, G. V. Truyols, E. Lundanes, T. Greibrokk
Chromatographia, 66 (2007) 469-474
12. Investigating the Effect of Chromatographic Conditions on Retention of Organic Acids in Hydrophilic Interaction Chromatography Using a Design of Experiment
Y. Guo, S. Srinivasan, S. Gaiki
Chromatographia, 66 (2007) 223-229
13. Hydrophilic Interaction Liquid Chromatographic Analysis of Aminohydroxyphenylalanines from Melanin Pigments
D. Nezirevic, K. Årstrand, B. Kågedal
J. Chromatogr. A, 1163 (2007) 70-79
14. An Enzymatic Deglycosylation Scheme Enabling Identification of Core Fucosylated N-Glycans and O-Glycosylation Site Mapping of Human Plasma Proteins
P. Hägglund, R. Matthiesen, F. Elortza, P. Højrup, P. Roepstorff, O. Nørregaard Jensen, J. Bunkenborg
J. Proteome Res., 6 (2007) 3021-3031
15. Application of a New Zwitterionic Hydrophilic Interaction Chromatography Column for Determination of Paralytic Shellfish Poisoning Toxins
M. Diener, K. Erler, B. Christian, B. Luckas
J. Sep. Sci., 30 (2007) 1821-1826
16. Improved Hydrophilic Interaction Chromatography Method for the Identification and Quantification of Glucosinolates
K. L. Wade, I. J. Garrard, J. W. Fahey
J. Chromatogr. A, 1154 (2007) 469-472
17. Simultaneous Determination of the Advanced Glycation End Product N-Carboxymethyllysine and its Precursor, Lysine, in Exhaled Breath Condensate using Isotope-Dilution Hydrophilic-Interaction Liquid Chromatography Coupled to Tandem Mass Spectrometry
T. Schettgen, A. Tings, C. Brodowsky, A. Müller-Lux, A. Musiol, T. Kraus
Anal. Bioanal. Chem., 384 (2007) 2783-2791
18. Evaluation and Optimization of ZIC-HILIC-RP as an Alternative MudPIT Strategy
P. J. Boersema, N. Divecha, A. J. R. Heck, S. Mohammed
J. Proteome Res., 6 (2007) 937-946
19. HPLC Columns Partition by Chemometric Methods Based on Peptides Retention
B. Buszewski, S. Kowalska, T. Kowalkowski, K. Rozp?dowska, M. Michel, T. Jonsson
J. Chromatogr. B, 845 (2007) 253-260
20. Structural Assignment of Disialylated Biantennary N-Glycan Isomers Derivatized with 2-Aminopyridine using Negative-ion Multistage Tandem Mass Spectral Matching
H. Ito, K. Yamada, K. Deguchi, H. Nakagawa, S.-I. Nishimura
Rapid. Commun. Mass Spectrom., 21 (2007) 212-218

21. Comparison of liquid chromatography and capillary electrophoresis methods for quantification of sodium residuals
W. Briône, C. Herbots, C. Köttgen, S. Loix, M. Gibella, M. Bertrand, A. Ceccato.
Journal of Pharmaceutical and Biomedical Analysis 44, (2007), 615-622
22. Analysis of variable N-glycosylation site occupancy in glycoproteins by liquid chromatography electrospray ionization mass spectrometry
J.E. Nettleship, R. Aplin, A.R. Aricescu, E.J. Evans, S.J. Davis, M. Crispin, R.J. Owens
Analytical Biochemistry 361, (2007), 149-151

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1. Separation and Identification of Phytosiderophores and their Metal Complexes in Plants by Zwitterionic Hydrophilic Interaction Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry
Y. Xuan, E. B. Scheuermann, A. R. Meda, H. Hayen, N. von Wirén, G. Weber
J. Chromatogr. A, 1136 (2006) 73-81
2. Direct Structural Assignment of Neutral and Sialylated N-Glycans of Glycopeptides using Collision-Induced Dissociation MSn Spectral Matching
H. Ito, Y. Takegawa, K. Deguchi, S. Nagai, H. Nakagawa, Y. Shinohara , S.-I. Nishimura
Rapid. Commun. Mass Spectrom., 20 (2006) 3557-3565
3. Simultaneous Determination of Positive and Negative Counterions Using a Hydrophilic Interaction Chromatography Method
D. S. Risley, B. W. Pack
LCGC North America, 24 (2006) 776-785 [pdf]
4. Simple Separation of Isomeric Sialylated N-Glycopeptides by a Zwitterionic Type of Hydrophilic Interaction Chromatography
Y. Takegawa, K. Deguchi, H. Ito, T. Keira, H. Nakagawa, S.-I. Nishimura
J. Sep. Sci., 29 (2006) 2533-2540
5. Isolation and Characterization of Glycosylphosphatidylinositol-Anchored Peptides by Hydrophilic Interaction Chromatography and MALDI Tandem Mass Spectrometry
M. J. Omaetxebarria, P. Hägglund, F. Elortza, N. M. Hooper, J. M. Arizmendi, Ole Nørregaard Jensen
Anal. Chem., 78 (2006) 3335-3341
6. Hydrophilic Interaction Chromatography [Review]
P. Hemström, K. Irgum
J. Sep. Sci., 29 (2006) 1784-1821
7. Separation of Isomeric 2-Aminopyridine Derivatized N-Glycans and N-glycopeptides of Human Serum Immunoglobulin G by Using a Zwitterionic Type of Hydrophilic-Interaction Chromatography
Y. Takegawa, K. Deguchi, T. Keira, H. Ito, H. Nakagawa, S.-I. Nishimura
J. Chromatogr. A, 1113 (2006) 177-181

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1. Metabolic Fingerprinting of Rat Urine by LC/MS: Part 1. Analysis by Hydrophilic Interaction Liquid Chromatography-Electrospray Ionization Mass Spectrometry
H. Idborg, L. Zamani, P.-O. Edlund, I. Schuppe-Koistinen, S. P. Jacobsson
J. Chromatogr. B, 828 (2005) 9-13
2. Metabolic Fingerprinting of Rat Urine by LC/MS: Part 2. Data Pretreatment Methods for Handling of Complex Data
H. Idborg, L. Zamani, P.-O. Edlund, I. Schuppe-Koistinen, S. P. Jacobsson
J. Chromatogr. B, 828 (2005) 14-20
3. On-line Desalting and Determination of Morphine, Morphine-3-glucuronide and Morphine-6-glucuronide in Microdialysis and Plasma Samples using Column Switching and Liquid Chromatography/Tandem Mass Spectrometry
J. Bengtsson, B. Jansson, M. Hammarlund-Udenaes
Rapid Commun. Mass Spectrom., 19 (2005) 2116-2122
4. Evaluation of the Separation of Acidic Compounds by Hydrophilic Interaction Liquid Chromatography (HILIC)
N. Nagae, T. Enami, and N. Fujita
G.I.T. Laboratory Journal, 5 (2005) 32-33

5. Retention Behavior of Small Polar Compounds on Polar Stationary Phases in Hydrophilic Interaction Chromatography
Y. Guo, S. Gaiki
J. Chromatogr. A, 1074 (2005) 71-80
6. Development and Validation of a Solid Phase Extraction-Liquid Chromatographic Method for the Determination of Amoxicillin in Plasma
N. Lindegårdh, T. Singtoroj, A. Annerberg, N. Day
Therapeutic Drug Monitoring, 27 (2005) 503-508

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1. A New Strategy for Identification of N-Glycosylated Proteins and Unambiguous Assignment of Their Glycosylation Sites Using HILIC Enrichment and Partial Deglycosylation
P. Hägglund, J. Bunkenborg, F. Elortza, O. Nørregaard Jensen, P. Roepstorff
J. Proteome Res., 3 (2004) 556-566

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