Next Generation Biopharmaceutical Downstream
Process (nextBioPharmDSP) Symposium
January 16, 2019 at the Golden LEAF Biomanufacturing Training and Education Center in Raleigh, NC
Join us to learn more about the work that has been done to achieve the objectives of the nextBiopharmDSP project:
Learn more about the nextBioPharmDSP project: http://nextbiopharmdsp.eu
- Primary separation: substitution of the standard process for primary separation with the utilization of flocculants and Tangential Flow Filtration (TFF).
- Continuous capture step: integration of continuous chromatography in the capture step and development
of novel disposable equipment for larger scale. Additionally non-chromatographic capture step alternatives,
such as continuous precipitation.
- Disposable DSP: evaluation of single-use disposable solutions for flow-through polishing steps for efficient removal of impurities and single pass TFF (SPTFF) as continuous product concentration approach.
- Advanced analytical tools: different tools for measuring impurities, product content and other parameters
in real time or close to real time.
Golden LEAF Biomanufacturing Training and Education Center
850 Oval Drive, Raleigh, NC 27606
Optimizing Biopharmaceutial Downstream Processing
for an Optimized Process
for primary separation,
capture and intermediate/
polishing steps will be
evaluated for the ability
to reduce the size and
number of downstream
unit operations and
Alternatives to batch
processing for the capture
step, such as continuous
chromatography, will be
evaluated to improve
efficiency and reduce the
need for expensive resins.
Precipitation will also be
evaluated as an approach
to replace protein A
as capture step.