Neurotransmitters are chemicals that carry signals from the presynaptic neuron, across the chemical synapse, to the postsynaptic neuron. Neurotransmitters define not only the neuropharmacology of a particular neuron, but also often an entire neurophysiological pathway or brain region. These specific neurotransmitters and neurotransmitter-producing enzymes are not typically restricted to perisynaptic regions but are localized to the cytoplasm. Antibodies against these targets often show broad cytoplasmic staining and make excellent markers for specific, neuropharmacologically defined, neuronal subtypes and pathways. Millipore has numerous Chemicon polyclonal and monoclonal antibodies targeting all identified neurotransmitters. Rabbit anti-Pan Voltage Gated Sodium Channel, SP19 (Catalog Number AB5210).
Rabbit anti-Pan Voltage Gated Sodium Channel, SP19 (Cat. No. AB5210). Staining of two myenteric ganglia with AB5210 (red) and an antibody to calbindin (green) which stained some of the neurons. Photo courtesy of Dr. W. Hartig, Leipzig University; Dr. M. Hanani, Hebrew University, Jerusalem.