On-Demand Webinar

Stainless Steel vs Single-Use Technologies

Duration: 1 Hour
Speaker: S├ębastien Ribault, Ph.D., Director, Bioproduction & Development, MilliporeSigma

Abstract: This webinar explains the benefits of using disposable equipment in your manufacturing process. We compare stainless steel, glass and single-use technologies, highlighting how comparable they are regarding titers and molecule quality, as well as the differences regarding operational and financial aspects. This webinar highlights studies performed to evaluate the performances of single-use equipment from early process development through to the manufactured drug substance using a fed-batch process. Process performance was compared in single-use, glass and stainless steel bioreactors. Several clinical runs at various scales using different types of cells such as CHO and NS0 and molecules including numerous mAbs and Fc-Fusion proteins were performed. We discuss how the results offer insights into scalability and comparability of the different systems and technologies. Finally, we review the time, resources and cost of the various operation options available to process developers.

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