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Purospher® STAR RP-18 Endcapped UHPLC Columns

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Where Speed Meets Performance.

Merck:/Freestyle/LE-Lab-Essentials/Chromatography/LE-Chrom-Hibar HR Purospher<sup>®</sup> STAR UHPLC columns-150x113-20140218.pngPurospher® STAR RP-18 endcapped UHPLC columns are designed for ultra-fast applications where resolution , sensitivity and sample throughput are crucial. This makes them ideal for high-throughput screening and quality control analyses, as well as process monitoring, method development, and LC-MS applications. Due to their balanced selectivity, Purospher® STAR RP-18 endcapped UHPLC columns deliver tailing-free chromatograms for a broad range of demanding separations.

Speed up Separations and Save Solvents

In routine HPLC laboratories, standard columns of 4.6 mm internal diameter (i.d.) are used for most applications. On average, such laboratories require 60 liters of solvent per year. The solvents used are mostly acetonitrile, methanol, isopropanol, hexane, and/or aqueous buffers. As a result, they generate 60 liters of mixed organic and aqueous waste annually. The use of columns with a 2.1 mm i.d. help you minimize waste as they reduce solvent consumption by up to 90%. In addition, MilliporeSigma’s UHPLC columns, packed with the reversed-phase sorbent Purospher® STAR RP-18 endcapped 2 µm, decrease separation time by a factor of 10.

Column Range

Purospher® STAR UHPLC columns are available in a variety of dimensions, packed with 2 µm or 3 µm particles. For difficult samples where clogging and high backpressure are of concern, we recommend Purospher® STAR RP-18 endcapped 3 µm columns.

Features and Benefits

  • Under UHPLC conditions, speed is increased by a factor of 10
  • Solvent consumption is drastically reduced by up to 90%
  • Excellent peak shapes for all acidic, basic and metal chelating analytes
  • Extraordinary stability from pH 1.5 to 10 for a wide application range
  • Enhanced sensitivity due to improved signal-to-noise ratio


Hibar® HR Purospher® STAR RP-18 endcapped

Separation of Alkylphenones

In the separation of alkylphenones, a 50-2.1 mm UHPLC column packed with Purospher® STAR reduces solvent consumption by 89% compared to a 150-4.6 mm column packed with Purospher®. Furthermore, separation time is decreased by a factor of 10.

High resolution separation of 9 alkylphenones

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