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Biological Information
Purity≥95% by HPLC
Physicochemical Information
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Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at -20°C. Prepare fresh as required.
Packaging Information
Packaged under inert gas Packaged under inert gas
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Documentation

p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

p53 Activator VII, STIMA-1 - CAS 91634-12-7 - Calbiochem Certificates of Analysis

TitleLot Number
506168

References

Reference overview
Zache, N., et al. 2008. Mol. Oncol. 2, 70.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-December-2010 RFH
Synonyms2-Vinyl-1H-quinazolin-4-one, SH group Targeting and Induction of Massive Apoptosis
DescriptionA cell-permeable styrylquinazoline compound that preferentially induces apoptotic death of mutant p53-harboring H1299-His175 and Saos-2-His273 tumor cells (IC50 = 3.4 and 4.9 µM, respectively), while exhibiting much reduced potency towards p53-null (IC50 = 9.6, 11.4, and 14.7 µM against H1299, Saos-2, and HCT116, respectively) or wild-type p53-expressing (IC50 = 13.2 and 20.3 µM against HCT116 and HDF, respectively) cells. STIMA-1 is demonstrated to covalently modify free thiols on mutant p53 in H1299-His175 cells and fully restore its DNA binding activity to the level seen with wild-type p53, resulting in upregulation of p53-dependent gene expression, including p21, PUMA, and Bax.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number91634-12-7
Chemical formulaC₁₀H₈N₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at -20°C. Prepare fresh as required.
Toxicity Standard Handling
ReferencesZache, N., et al. 2008. Mol. Oncol. 2, 70.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Inducers > Apoptosis Inducers