506158 p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem

506158
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₉H₈N₂O 1670-87-7

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506158-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
      Catalogue Number506158
      Brand Family Calbiochem®
      SynonymsIndole-5-carboxamide
      References
      ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.
      Product Information
      CAS number1670-87-7
      FormOff-white solid
      Hill FormulaC₉H₈N₂O
      Chemical formulaC₉H₈N₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-36/37/38

      Harmful if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      506158

      References

      Reference overview
      Medicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-March-2009 RFH
      SynonymsIndole-5-carboxamide
      DescriptionA cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38α MAP kinase inhibitor (IC50 = 3.2 nM). It inhibits p38β only at much higher concentrations (IC50 = 122 nM) and exhibits little activity against p38γ, ERK2, JNK-1, or MAPKAPK-2 even at concentrations as high as 50 µM. When administered to NOD mice via food intake in vivo, SD-169 is shown to prevent the development of type 1 diabetes in prediabetic mice and display therapeutic efficacy in treating animals already in mild and moderate hyperglycemic states.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1670-87-7
      Chemical formulaC₉H₈N₂O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml) or H2O (1 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesMedicherla, S., et al. 2006. J. Pharmacol. Exp. Ther. 318, 99.