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682162 Xestospongin D, Xestospongia sp. - Calbiochem

A reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC₅₀ = 648 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: XeD

Primary Target: IP3-mediated Ca2+
682162
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₈H₅₀N₂O₃

Pricing & Availability

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682162-50UG
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      		 Plastic ampoule 50 μg
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      Description
      OverviewA reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM). Also displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).
      Catalogue Number682162
      Brand Family Calbiochem®
      SynonymsXeD
      References
      ReferencesGafni, J., et al. 1997. Neuron 19, 723.
      Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
      Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
      Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
      Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227
      Product Information
      ATP CompetitiveN
      FormClear film
      Hill FormulaC₂₈H₅₀N₂O₃
      Chemical formulaC₂₈H₅₀N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIP3-mediated Ca2+
      Primary Target IC<sub>50</sub>648 nM in blocking IP3-mediated Ca2+ release
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Xestospongin D, Xestospongia sp. - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Xestospongin D, Xestospongia sp. - Calbiochem Certificates of Analysis

      TitleLot Number
      682162

      References

      Reference overview
      Gafni, J., et al. 1997. Neuron 19, 723.
      Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
      Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
      Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
      Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      SynonymsXeD
      DescriptionA membrane-permeable, reversible blocker of IP3-mediated Ca2+ release (IC50 = 648 nM) that is less potent than XeC (Cat. No. 682160). Also displays a high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R).
      FormClear film
      Chemical formulaC₂₈H₅₀N₂O₃
      Structure formulaStructure formula
      Purity≥90% by TLC
      SolubilityEthanol (1 mg/ml), or methanol (1 mg/ml). Sonication may be required to achieve complete solubilization.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesGafni, J., et al. 1997. Neuron 19, 723.
      Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
      Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
      Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
      Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227

      Related Products & Applications

      Alternative Products

      Catalog Number Description  
      682160 Xestospongin C, Xestospongia sp. - Calbiochem Show Pricing & Availability

      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Calcium Signaling > IP3 and Ryanodine Channel Modulators