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504396 VU0155041, Sodium Salt - Calbiochem

VU0155041, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: cis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt

504396
  
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄H₁₄Cl₂NNaO₃
      Description
      OverviewA highly potent, selective positive allosteric modulator for mGlu receptor subtype 4 (EC50 = 0.8 and 0.7 µM at human and rat mGlu4 receptors respectively). Does not interact with other mGluR subtypes. Significant antiparkinsonian effects in two preclinical rodent models of Parkinson's disease when administered intracerebroventricularlly (icv).
      Catalogue Number504396
      Brand Family Calbiochem®
      Synonymscis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt
      References
      ReferencesNiswender, C., et al. 2008. Mol. Pharmacol. 74, 1345.
      Duan, Z., et al. 2013. Cell Mol. Biol. 59, 1809.
      Guimaraes-Souza E., et al. 2012. J. Neurosci. Res. 90, 2349.
      Betts, M., et al. 2012. Br. J. Pharmacol. 166, 2317.
      Williams, R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 4967.
      Product Information
      FormWhite solid
      Hill FormulaC₁₄H₁₄Cl₂NNaO₃
      Chemical formulaC₁₄H₁₄Cl₂NNaO₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Niswender, C., et al. 2008. Mol. Pharmacol. 74, 1345.
      Duan, Z., et al. 2013. Cell Mol. Biol. 59, 1809.
      Guimaraes-Souza E., et al. 2012. J. Neurosci. Res. 90, 2349.
      Betts, M., et al. 2012. Br. J. Pharmacol. 166, 2317.
      Williams, R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 4967.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonymscis-2-(3,5-Dichlorophenylcarbamoyl)cyclohexanecarboxylic acid sodium salt
      DescriptionA highly potent, selective positive allosteric modulator for mGlu receptor subtype 4 (EC50 = 0.8 and 0.7 µM at human and rat mGlu4 receptors respectively). Does not interact with other mGluR subtypes. Significant antiparkinsonian effects in two preclinical rodent models of Parkinson's disease when administered intracerebroventricularlly (icv).
      FormWhite solid
      Chemical formulaC₁₄H₁₄Cl₂NNaO₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNiswender, C., et al. 2008. Mol. Pharmacol. 74, 1345.
      Duan, Z., et al. 2013. Cell Mol. Biol. 59, 1809.
      Guimaraes-Souza E., et al. 2012. J. Neurosci. Res. 90, 2349.
      Betts, M., et al. 2012. Br. J. Pharmacol. 166, 2317.
      Williams, R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 4967.