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662105 Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem

662105
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₇H₁₃N₃O₇ • 3H₂O

Pricing & Availability

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662105-25MG
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      Plastic ampoule 25 mg
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      Description
      OverviewA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
      Catalogue Number662105
      Brand Family Calbiochem®
      Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
      References
      ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.
      Product Information
      FormDark purple solid
      Hill FormulaC₁₇H₁₃N₃O₇ • 3H₂O
      Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationUbiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).
      Biological Information
      Purity≥90% by HPLC (sum of two isomers)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-24/25-36-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem Certificates of Analysis

      TitleLot Number
      662105

      References

      Reference overview
      Yang, Y., et al. 2007. Cancer Res. 67, 9472.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-March-2009 RFH
      Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
      DescriptionA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
      FormDark purple solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
      Structure formulaStructure formula
      Purity≥90% by HPLC (sum of two isomers)
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
      Toxicity Irritant
      ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.